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Sponsors and Collaborators: |
National Institute on Drug Abuse (NIDA) Wayne State University |
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Information provided by: | National Institute on Drug Abuse (NIDA) |
ClinicalTrials.gov Identifier: | NCT00608504 |
The purpose is to study how certain factors, including money, the amount of drug available and the amount of work effort, affect opiate drug choice.
Condition |
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Heroin Dependence Opioid-Related Disorders |
Study Type: | Observational |
Study Design: | Case-Only, Prospective |
Official Title: | Biobehavioral Study of Opioid Drug Seeking Behavior: Study 3 |
Whole blood
Estimated Enrollment: | 16 |
Study Start Date: | July 2007 |
Study Completion Date: | April 2009 |
Primary Completion Date: | April 2009 (Final data collection date for primary outcome measure) |
A drug dependent person chooses to take drug more often (and suffer its long-term bad consequences) than choosing to engage in healthy activities (which have better long-term consequences). The present research will be conducted in a controlled laboratory setting with heroin abusers who are not seeking treatment to understand what factors guide their choices.
This research focuses on environmental (i.e. non-medication) factors that affect choosing a drug versus money. Findings from this research are likely to be important in developing a theoretical and practical basis for behavioral interventions as part of drug abuse treatment. HYD is a drug that is currently used as a cough suppressant and to relieve pain.
Participants in this observational study will take part in multiple trials in which they have the opportunity to choose HYD or money. On the first two experimental days, prior to choice sessions, participants will receive a sample of the drug doses that can be chosen. During test sessions, participants will have 12 opportunities to choose either drug or money. Participants will use a computer to earn choices. Respiration rate, oxygen saturation, heart rate, and blood pressure will be monitored throughout choice trials. Self-report questionnaires will be completed at different times during the study.
Participants will be maintained on buprenorphine throughout the study, with a minimum 2-week lead before the experiment, and a fixed 3-week detoxification after study completion.
Ages Eligible for Study: | 18 Years to 55 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Heroin dependent research volunteers
Inclusion Criteria:
Exclusion Criteria:
United States, Michigan | |
Wayne State University | |
Detroit, Michigan, United States, 48202 |
Principal Investigator: | Mark Greenwald, PhD | Wayne State University |
Responsible Party: | Wayne State University ( Mark Greenwald Ph.D. ) |
Study ID Numbers: | NIDA-15462-3, R01-DA015462-3, DPMCDA |
Study First Received: | January 31, 2008 |
Last Updated: | April 13, 2009 |
ClinicalTrials.gov Identifier: | NCT00608504 History of Changes |
Health Authority: | United States: Food and Drug Administration; United States: Federal Government |
Behavioral Economics Drug self administration Opioid |
Mental Disorders Heroin Dependence Substance-Related Disorders Central Nervous System Depressants Disorders of Environmental Origin |
Peripheral Nervous System Agents Analgesics Opioid-Related Disorders Analgesics, Opioid |
Heroin Dependence Physiological Effects of Drugs Central Nervous System Depressants Disorders of Environmental Origin Opioid-Related Disorders Pharmacologic Actions Mental Disorders |
Sensory System Agents Therapeutic Uses Substance-Related Disorders Analgesics Peripheral Nervous System Agents Central Nervous System Agents Analgesics, Opioid |