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| Sponsored by: |
University of Sao Paulo |
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| Information provided by: | University of Sao Paulo |
| ClinicalTrials.gov Identifier: | NCT00666510 |
Purpose
Intraoperative bronchospasm challenges anesthesia's safety. This study aims to investigate high concentration of exhaled nitric oxide as a marker of intraoperative bronchospasm.
| Condition |
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Asthma Airway Hyperresponsiveness |
| Study Type: | Observational |
| Study Design: | Case Control, Retrospective |
| Official Title: | Higher Exhaled Nitric Oxide (NO) is Associated With Intraoperative Bronchospasm |
Sputum
| Enrollment: | 31 |
| Study Start Date: | January 1999 |
| Study Completion Date: | December 2004 |
| Groups/Cohorts |
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Bronchospasm
Patients who presented bronchospasm during anesthesia induction
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Asthma
Patients who presented bronchospasm during anesthesia induction and were identified as asthmatics
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Control
Patients who were submitted to anesthesia induction and showed no complications
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Previous studies in asthmatic patients suggested that exhaled nitric oxide may represent a noninvasive measure for airway inflammation. Anesthesia information forms from 1999 throughout 2004 were revised (n=146.358). Bronchospasm occurrence appeared registered on 863 forms. From those, nine were identified as non-asthmatics patients (Bronchospasm group). Also, 12 asthmatics constituted one additional group (Asthma group) and 10 subjects with no previous airway disease or symptoms (Control group). All subjects were submitted to Exhaled nitric oxide measurements (parts/billion), spirometry and induced sputum.
Eligibility| Ages Eligible for Study: | 16 Years to 65 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Hospital, late post-anesthesia cared patients
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Brazil | |
| Hospital das Clínicas da FMUSP | |
| São Paulo, Brazil, 05430 010 | |
| Principal Investigator: | Joaquim E Vieira, MD, PhD | University of Sao Paulo Medical School - FMUSP |
More Information
| Responsible Party: | Fisiopatologia Experimental FMUSP ( Joaquim Edson Vieira ) |
| Study ID Numbers: | CAP125-01 |
| Study First Received: | April 23, 2008 |
| Last Updated: | April 23, 2008 |
| ClinicalTrials.gov Identifier: | NCT00666510 History of Changes |
| Health Authority: | Brazil: National Committee of Ethics in Research |
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nitric oxide bronchospasm anesthesia induced sputum asthma |
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Spasm Vasodilator Agents Neurotransmitter Agents Antioxidants Bronchial Spasm Bronchial Diseases Anti-Asthmatic Agents Asthma Anesthetics Cardiovascular Agents |
Nitric Oxide Lung Diseases, Obstructive Hypersensitivity Respiratory Tract Diseases Lung Diseases Hypersensitivity, Immediate Peripheral Nervous System Agents Bronchodilator Agents Respiratory Hypersensitivity |
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Respiratory System Agents Neurotransmitter Agents Vasodilator Agents Bronchial Spasm Antioxidants Bronchial Diseases Molecular Mechanisms of Pharmacological Action Physiological Effects of Drugs Hypersensitivity Lung Diseases, Obstructive Respiratory Tract Diseases Therapeutic Uses Free Radical Scavengers Endothelium-Dependent Relaxing Factors |
Immune System Diseases Asthma Anti-Asthmatic Agents Cardiovascular Agents Protective Agents Pharmacologic Actions Nitric Oxide Autonomic Agents Lung Diseases Hypersensitivity, Immediate Peripheral Nervous System Agents Bronchodilator Agents Respiratory Hypersensitivity |
