Home
Search
Study Topics
Glossary
|
|
|
|
|
Sponsored by: |
Far Eastern Memorial Hospital |
---|---|
Information provided by: | Far Eastern Memorial Hospital |
ClinicalTrials.gov Identifier: | NCT00711685 |
Sternal or mediastinal infections after heart operation occurs infrequently but carries a high cost in money, morbidity, and mortality. At our hospital, Staphylococcus species cause most of these infections and is uniformly sensitive to vancomycin. However, the relative low concentration of vancomycin in sternal bone was noted given intravenously. Topical vancomycin was therefore considered to apply on the cut edege of sternal bone before closure in patients receiving coronary artery bypass graft to evaluate the effect on reducing the infection rate of staphylococcus related mediastinitis (6). In addition, we try to observe that prophylactic use of topical vancomycin will increase the risk for acquiring resistant pathogen such as VISA (vancomycin-intermediate S. aureus), VRSA (Vancomycin-resistant S. aureus), VRE (vancomycin-resistant enterococcus)
Condition | Intervention |
---|---|
Coronary Artery Disease |
Procedure: coronary artery bypass grafting via midline sternotomy |
Study Type: | Interventional |
Study Design: | Prevention, Non-Randomized, Open Label, Active Control, Parallel Assignment, Efficacy Study |
Official Title: | Topical Vancomycin in Prevention of Methicillin-Resistant Staphylococcal Related Mediastinitis in Patients Receiving Coronary Artery Bypass Graft |
Estimated Enrollment: | 50 |
Study Start Date: | January 2007 |
Primary Completion Date: | December 2007 (Final data collection date for primary outcome measure) |
Ages Eligible for Study: | 20 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Responsible Party: | Far Eastern Memorial Hospital ( Far Eastern Memorial Hospital ) |
Study ID Numbers: | 95033, FEMH-95-C-040 |
Study First Received: | July 7, 2008 |
Last Updated: | July 8, 2008 |
ClinicalTrials.gov Identifier: | NCT00711685 History of Changes |
Health Authority: | Taiwan: Department of Health |
Topical vancomycin mediastinitis coronary artery |
bypass graft Patients |
Arterial Occlusive Diseases Heart Diseases Myocardial Ischemia Thoracic Diseases Vascular Diseases Ischemia Arteriosclerosis Mediastinitis |
Coronary Disease Anti-Bacterial Agents Methicillin Respiratory Tract Diseases Vancomycin Coronary Artery Disease Mediastinal Diseases |
Arterial Occlusive Diseases Anti-Infective Agents Heart Diseases Myocardial Ischemia Thoracic Diseases Vascular Diseases Arteriosclerosis Mediastinitis Pharmacologic Actions |
Coronary Disease Anti-Bacterial Agents Methicillin Respiratory Tract Diseases Therapeutic Uses Vancomycin Cardiovascular Diseases Coronary Artery Disease Mediastinal Diseases |