Home
Search
Study Topics
Glossary
|
|
|
|
|
|
Sponsored by: |
University of Alberta |
---|---|
Information provided by: | University of Alberta |
ClinicalTrials.gov Identifier: | NCT00406705 |
The purpose of this study is to examine whether breathing helium-hyperoxia during exercise in a pulmonary rehabilitation program can improve the exercise tolerance and health related quality of life of patients with Chronic Obstructive Pulmonary Disease (COPD).
Condition | Intervention | Phase |
---|---|---|
Chronic Obstructive Pulmonary Disease COPD Emphysema Lung Diseases Bronchitis, Chronic |
Behavioral: Helium-Hyperoxia |
Phase II |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double-Blind, Active Control, Parallel Assignment, Efficacy Study |
Official Title: | A Randomized Controlled Trial to Study the Effect of Exercise Training Breathing Helium-Hyperoxia on The Exercise Tolerance and Quality of Life of Patients With Chronic Obstructive Pulmonary Disease |
Estimated Enrollment: | 38 |
Study Start Date: | March 2005 |
Study Completion Date: | January 2007 |
It is well accepted that the exercise training as part of a comprehensive pulmonary rehabilitation program can improve exercise tolerance, functional status and quality of life in patients with COPD. It is feasible that if patients were able to perform a greater volume or intensity of exercise during rehabilitation then the outcomes of the program would be improved. Recent research has demonstrated that breathing a helium-hyperoxic gas mixture can significantly reduce dynamic hyperinflation and dyspnea during exercise in patients with COPD and can increase exercise tolerance to a greater extent than breathing room air or a nitrogen-based hyperoxic gas. If patients with COPD were to breathe a helium-hyperoxic gas during exercise they should be able to tolerate a greater intensity of exercise while maintaining similar levels of exertional symptoms to those observed at lower exercise intensities breathing room air. As a result patients randomized to the helium-hyperoxia condition should obtain greater improvements in exercise tolerance than those receiving usual care (i.e. breathing room air)
Comparisons: Standard pulmonary rehabilitation of patients with COPD receiving either usual care (air breathing) or helium-hyperoxia (40% O2, 60% Helium).
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Canada, Alberta | |
Caritas Centre for Lung Health | |
Edmonton, Alberta, Canada, T5K 0L4 |
Principal Investigator: | Neil D Eves, PhD | University of Calgary, AB, Canada |
Study ID Numbers: | MSI 824 |
Study First Received: | November 29, 2006 |
Last Updated: | May 3, 2007 |
ClinicalTrials.gov Identifier: | NCT00406705 |
Health Authority: | Canada: Ethics Review Committee |
Exercise Tolerance Dyspnea Rehabilitation Helium |
Emphysema Respiration Disorders Quality of Life Pulmonary Emphysema Hyperoxia Bronchitis, Chronic Lung Diseases, Obstructive |
Respiratory Tract Diseases Respiratory Tract Infections Lung Diseases Bronchitis Dyspnea Pulmonary Disease, Chronic Obstructive |
Pathologic Processes Bronchial Diseases |