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Sponsors and Collaborators: |
M.D. Anderson Cancer Center University of Michigan |
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Information provided by: | M.D. Anderson Cancer Center |
ClinicalTrials.gov Identifier: | NCT00037843 |
This is a clinical research study using I-131 Iodocholesterol which is an experimental radioactive chemical that when injected into the vein, is picked up in the adrenal glands and permits visualization with gamma imaging devices. These images are used in diagnosing a variety of adrenal abnormalities.Prior to the injection of I-131 Iodocholesterol, the patient will receive perchlorate capsules to block any uptake of I-131 by the thyroid gland if this is deemed important. The patient will continue to take these capsules throughout the period of imaging, which may last up to 1 week. The injection of I-131 Iodocholesterol will be given into a vein and the patient will return for images on at least 1 and possibly 2 occasions between 3-7 days after injection. If the case requires it, the patient may also be given a steroid in tablet form, dexamethasone, to take orally prior to and after the injection to suppress normal adrenal function so that the abnormal tissues can be more easily detected.
Condition | Intervention | Phase |
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Adrenal Gland Diseases Adrenal Gland Neoplasms |
Drug: I-131 Iodocholesterol |
Phase III |
Study Type: | Interventional |
Study Design: | Diagnostic, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Safety Study |
Official Title: | Iodine I-131 Iodocholesterol, Its Use in Adrenal Screening |
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Adults with suspected adrenal disease, such as adrenal adenoma, carcinoma, hyperplasia, or Addison's Disease.
United States, Texas | |
University of Texas M.D. Anderson Cancer Center | |
Houston, Texas, United States, 77030 |
Principal Investigator: | Donald A. Podoloff, MD | U.T. M.D. Anderson Cancer Center |
Study ID Numbers: | NUM88-001 |
Study First Received: | May 23, 2002 |
Last Updated: | October 8, 2007 |
ClinicalTrials.gov Identifier: | NCT00037843 |
Health Authority: | United States: Food and Drug Administration |
adrenal diseases |
Adrenal Gland Neoplasms Iodine Endocrine System Diseases Adrenal Gland Diseases |
Endocrinopathy Epinephrine Endocrine Gland Neoplasms |
Neoplasms Neoplasms by Site |