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Sponsored by: |
National Human Genome Research Institute (NHGRI) |
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Information provided by: | National Institutes of Health Clinical Center (CC) |
ClinicalTrials.gov Identifier: | NCT00339885 |
The aim of the project is to positionally clone susceptibility genes for NIDDM. Patients will be ascertained in Finland from previous health surveys and hospital discharge records. Approximately 400 affected sib pairs will be collected. Families will be chosen who have, at most, one parent with NIDDM no history of IDDM. A clinical examination will be undertaken on family members and blood drawn for DNA isolation. Covariates such as body weight, blood pressure, lipid levels and urinary albumin will also be measured. The unaffected spouse and children of a subset of probands will be invited to undergo a frequently-sampled intravenous glucose tolerance test (FSIGT) to measure parameters of pancreatic function and peripheral insulin resistance (IR). A number of unrelated elderly non-diabetic subjects will also be identified to conduct a population-based association analysis.
The FSIGT analysis will be performed in Los Angeles. The DNA will be shipped to Bethesda where a total genomic scan will be performed using semi-automated fluorescence-based genotyping technology. Data from Bethesda, Los Angeles and Finland will be sent to Ann Arbor where parametric and non-parametric methods will be used to analyse both discrete traits such as NIDDM and intermediate traits like IR.
Condition |
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Non-Insulin Dependent Diabetes Mellitus |
Study Type: | Observational |
Official Title: | Mapping Genes for Non-Insulin Dependent Diabetes Mellitus |
Study Start Date: | March 1995 |
The Finland-United States investigation of NIDDM (FUSION) study is a long-term effort to identify susceptibility genes for Type 2 diabetes (T2D) and associated quantitative traits. This involves the phenotyping and DNA analysis of thousands of individuals living in Finland, utilizing a study design that was originally based on affected sib pairs. The majority of these samples have already been subjected to a genome scan using microsatellite markers. More recently, with the opportunity provided by HapMap and dramatically lowered genotyping costs, the original FUSION samples plus thousands of other cases and controls are being subjected to genome-wide association of (GWA) analysis.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Contact: Ann C. M. Smith | (301) 435-5475 | acmsmith@nhgri.nih.gov |
United States, District of Columbia | |
Howard University Hospital | Recruiting |
Washington, District of Columbia, United States, 20060 | |
Finland | |
University of Kuopio | Recruiting |
Kuopio, Finland | |
National Public Health Institute | Recruiting |
Helsinki, Finland | |
Helsinki University Hospital District | Recruiting |
Helsinki, Finland | |
Research Ethics Committee of Hospital District of Northern Savo | Recruiting |
Savo, Finland | |
Germany | |
Technical University | Recruiting |
Dresden, Germany | |
Norway | |
HUNT Research Center and Biobank | Recruiting |
Trondheim, Norway | |
University of Science and Technology (NTNU) | Recruiting |
Trondheim, Norway |
Study ID Numbers: | 999995030, OH95-HG-N030 |
Study First Received: | June 19, 2006 |
Last Updated: | July 18, 2008 |
ClinicalTrials.gov Identifier: | NCT00339885 |
Health Authority: | United States: Federal Government |
Type 2 Diabetes |
Metabolic Diseases Diabetes Mellitus, Type 2 Diabetes Mellitus Endocrine System Diseases |
Endocrinopathy Metabolic disorder Glucose Metabolism Disorders |