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Antiproteinuric Efficacy of Losartan Potassium in Patients With Non-Diabetic Proteinuric Renal Diseases
This study is ongoing, but not recruiting participants.
Sponsored by: Merck
Information provided by: Merck
ClinicalTrials.gov Identifier: NCT00140985
  Purpose

Antiproteinuric Efficacy of Losartan Potassium in Patients with Non-Diabetic Proteinuric Renal Diseases.


Condition Intervention Phase
Renal Disorder
Drug: MK0954, losartan potassium/Duration of Treatment: 20 weeks
Drug: Comparator: amlodipine / Duration of Treatment: 20 weeks
Phase IV

Drug Information available for: Losartan Losartan potassium Amlodipine Amlodipine besylate Potassium chloride
U.S. FDA Resources
Study Type: Interventional
Study Design: Treatment, Randomized, Double-Blind, Active Control, Parallel Assignment, Efficacy Study
Official Title: Antiproteinuric Efficacy of Losartan Potassium in Patients With Non-Diabetic Proteinuric Renal Diseases

Further study details as provided by Merck:

Primary Outcome Measures:
  • 24h proteinuria

Secondary Outcome Measures:
  • Changes in the plasma and urinary levels of TGF-beta

Estimated Enrollment: 98
Study Start Date: January 2000
  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Males or females at least 18 years of age with non-diabetic proteinuric renal diseases
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00140985

Locations
Spain
Merck Sharp & Dohme De Espana, S.A.E.
Madrid, Spain, 28027
Sponsors and Collaborators
Merck
Investigators
Study Director: Medical Monitor Merck
  More Information

Study ID Numbers: 2005_058
Study First Received: August 30, 2005
Last Updated: October 25, 2005
ClinicalTrials.gov Identifier: NCT00140985  
Health Authority: Spain: Ministry of Health

Study placed in the following topic categories:
Losartan
Urologic Diseases
Kidney Diseases
Angiotensin II
Amlodipine

Additional relevant MeSH terms:
Angiotensin II Type 1 Receptor Blockers
Molecular Mechanisms of Pharmacological Action
Therapeutic Uses
Cardiovascular Agents
Anti-Arrhythmia Agents
Antihypertensive Agents
Pharmacologic Actions

ClinicalTrials.gov processed this record on January 13, 2009