Combination Chemotherapy and Total-Body Irradiation Followed by Peripheral Stem Cell or Bone Marrow Transplantation in Treating Patients With Acute Lymphoblastic Leukemia - Full Text View

Sponsors and Collaborators:	Fred Hutchinson Cancer Research Center National Cancer Institute (NCI)
Information provided by:	National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:	NCT00027547

Purpose

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy and radiation therapy. Sometimes the transplanted cells are rejected by the body's normal tissues. Mycophenolate mofetil and donor white blood cells may prevent this from happening.

PURPOSE: Phase I/II trial to determine the effectiveness of combination chemotherapy and total-body irradiation followed by peripheral stem cell transplantation in treating patients who have acute lymphoblastic leukemia.

Condition	Intervention	Phase
Leukemia	Drug: cyclosporine Drug: cytarabine Drug: fludarabine phosphate Drug: methotrexate Drug: mycophenolate mofetil Drug: therapeutic allogeneic lymphocytes Procedure: allogeneic bone marrow transplantation Procedure: peripheral blood stem cell transplantation Procedure: radiation therapy	Phase I Phase II

MedlinePlus related topics: Bone Marrow Transplantation Cancer Leukemia, Adult Acute Leukemia, Adult Chronic Leukemia, Childhood

Drug Information available for: Cytarabine Cytarabine hydrochloride Methotrexate Fludarabine Fludarabine monophosphate Cyclosporin Cyclosporine Mycophenolate Mofetil Mycophenolate mofetil hydrochloride

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Open Label
Official Title:	Nonmyeloablative Allogeneic Hematopoietic Cell Transplantation From HLA Matched Sibling Donors For Treatment Of Patients With High Risk Acute Lymphocytic Leukemia In Complete Remission

Further study details as provided by National Cancer Institute (NCI):

Study Start Date:

July 2001

Detailed Description:

OBJECTIVES:

Determine if a one-year disease free survival of 40% and a day 200 transplant-related mortality of less than 25% can be achieved in patients with high-risk acute lymphoblastic leukemia in complete remission treated with a nonmyeloablative conditioning regimen comprising fludarabine and total body irradiation followed by allogeneic peripheral blood stem cell or bone marrow transplantation.
Evaluate the efficacy and toxicity of donor lymphocyte infusion in the treatment of minimal residual disease after nonmyeloablative allografting in these patients.

OUTLINE: This is a multicenter study.

Patients receive a nonmyeloablative conditioning regimen comprising fludarabine IV on days -4 to -2 and total body irradiation (TBI) on day 0. Children undergo allogeneic peripheral blood stem cell transplantation (PBSCT) or bone marrow transplantation after TBI on day 0. Adults undergo filgrastim (G-CSF)-mobilized allogeneic PBSCT after TBI on day 0.

Patients also receive graft-versus-host disease (GVHD) prophylaxis therapy comprising oral cyclosporine twice daily on days -3 to 56 and then tapered and oral mycophenolate mofetil once at 5-10 hours after transplantation on day 0 and then twice daily on days 1-27.

Patients who have no evidence of grade 2 or greater acute GVHD or clinically extensive chronic GVHD, have been off GVHD prophylaxis therapy for 1-2 weeks, and have stable or increasing minimal residual disease after discontinuation of GVHD prophylaxis therapy receive donor lymphocyte infusion (DLI) IV over 30 minutes. DLI repeats every 4 weeks for a total of 3 doses (if necessary).

Patients without a history of CNS leukemia and patients with a history of CNS leukemia previously treated with prophylactic craniospinal irradiation receive methotrexate (MTX) or cytarabine (ARA-C) intrathecally (IT) for a total of 2 doses before transplantation and for a total of 6 doses beginning on day 32 after transplantation. Patients with a history of CNS leukemia not previously treated with craniospinal irradiation undergo craniospinal irradiation for 11 days before conditioning regimen and then MTX or ARA-C IT for a total of 6 doses beginning on day 32 after transplantation. Male patients also undergo testicular radiotherapy for 7 days.

Patients are followed at 1, 2, 3, 6, 12, 18, and 24 months.

PROJECTED ACCRUAL: A total of 30 patients (20 adults and 10 children) will be accrued for this study within 2 years.

Eligibility

Ages Eligible for Study:	up to 75 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

DISEASE CHARACTERISTICS:

Diagnosis of acute lymphoblastic leukemia (ALL)
Adult patients must meet 1 of the following criteria:
- Age 50 to 75 with high-risk ALL in complete remission (CR) (less than 5% blasts by morphology on bone marrow aspirate and absence of peripheral blasts) or ALL in second CR (CR2) or greater
- Age 18 to 50 with high-risk ALL in first CR (CR1) and either ineligible for conventional allogeneic transplantation (based on general medical condition) or refused conventional transplantation
  - High-risk adult ALL in CR1 includes patients meeting 1 or more of the following criteria:
    - Age 30 and over
    - Non-T-cell phenotype
    - Cytogenetic abnormalities including t(9;22), t(4;11), trisomy 8, or monosomy 7
    - Failure to achieve CR after 4 weeks of induction chemotherapy
- Age 18 to 50 with ALL in CR2 or greater and ineligible for conventional allogeneic transplantation based on general medical condition
- Age 18 to 50 with high-risk ALL in CR2 or greater and refused conventional allogeneic transplantation
Pediatric patients must meet 1 of the following criteria:
- Under age 18 with high-risk ALL in CR1 and ineligible for conventional allogeneic transplantation based on general medical condition
  - High-risk pediatric ALL in CR1 includes patients meeting 1 or more of the following criteria:
    - Cytogenetic abnormalities
      - t(9;22) with WBC at least 25,000/mm3 at diagnosis
      - t(4;11) in patients under age 1 or age 10 and over
      - Hypodiploidy (no more than 45 chromosomes)
    - Failure to achieve CR after 4 weeks of induction chemotherapy
    - Persistent peripheral blasts after 1 week of induction chemotherapy
- Under age 18 with CR2 or greater and ineligible for conventional allogeneic transplantation based on general medical condition
- Age 12 and under allowed if approved by the principle investigator
No active CNS disease
Availability of a sibling donor (excluding an identical twin)
- HLA genotypically identical for at least 1 haplotype
- HLA-A, -B, -C, -DRB1, and -DQB1 genotypically or phenotypically identical

PATIENT CHARACTERISTICS:

Age:

See Disease Characteristics
75 and under

Performance status:

Karnofsky 50-100% (adults)
Lansky 40-100% (children)

Life expectancy:

Not specified

Hematopoietic:

See Disease Characteristics

Hepatic:

No fulminant liver failure
No alcoholic hepatitis
No history of bleeding esophageal varices
No grade II or greater hepatic encephalopathy
No hepatic synthetic dysfunction evidenced by prolongation of PT with INR greater than 2.5
No intractable ascites related to portal hypertension
No bacterial or fungal liver abscess
No chronic viral hepatitis with bilirubin greater than 5 mg/dL
No biliary obstruction with bilirubin greater than 5 mg/dL
No concurrent symptomatic biliary disease

Renal:

Not specified

Cardiovascular:

Cardiac ejection fraction at least 30%

Pulmonary:

No requirement for supplementary continuous oxygen

Other:

HIV negative
Not pregnant or nursing
Fertile patients must use effective contraception during and for 1 year after study participation

PRIOR CONCURRENT THERAPY:

Biologic therapy

No concurrent posttransplantation growth factors during mycophenolate mofetil administration

Chemotherapy

See Disease Characteristics

Endocrine therapy

Not specified

Radiotherapy

Not specified

Surgery

Not specified

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00027547

Locations

United States, Oregon
Cancer Institute at Oregon Health and Science University
Portland, Oregon, United States, 97239
United States, Washington
Fred Hutchinson Cancer Research Center
Seattle, Washington, United States, 98109-1024
Germany
Universitaet Leipzig
Leipzig, Germany, D-04103

Sponsors and Collaborators

Fred Hutchinson Cancer Research Center

National Cancer Institute (NCI)

Investigators

Study Chair:

George Georges, MD

Fred Hutchinson Cancer Research Center

More Information

Clinical trial summary from the National Cancer Institute's PDQ® database This link exits the ClinicalTrials.gov site

Study ID Numbers:	CDR0000069042, FHCRC-1586.00, NCI-H01-0080
Study First Received:	December 7, 2001
Last Updated:	July 23, 2008
ClinicalTrials.gov Identifier:	NCT00027547
Health Authority:	United States: Federal Government

Keywords provided by National Cancer Institute (NCI):

adult acute lymphoblastic leukemia in remission
childhood acute lymphoblastic leukemia in remission

Study placed in the following topic categories:

Leukemia, Lymphoid
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Immunoproliferative Disorders
Cyclosporine
Clotrimazole
Miconazole
Tioconazole
Fludarabine monophosphate
Cyclosporins
Acute lymphoblastic leukemia, adult

Folic Acid
Leukemia
Lymphatic Diseases
Mycophenolate mofetil
Methotrexate
Fludarabine
Lymphoproliferative Disorders
Lymphoma
Cytarabine

Additional relevant MeSH terms:

Antimetabolites
Anti-Infective Agents
Antimetabolites, Antineoplastic
Neoplasms by Histologic Type
Immune System Diseases
Molecular Mechanisms of Pharmacological Action
Immunologic Factors
Antineoplastic Agents
Physiological Effects of Drugs
Enzyme Inhibitors
Reproductive Control Agents
Folic Acid Antagonists

Abortifacient Agents, Nonsteroidal
Antiviral Agents
Immunosuppressive Agents
Pharmacologic Actions
Neoplasms
Antifungal Agents
Therapeutic Uses
Abortifacient Agents
Antirheumatic Agents
Dermatologic Agents
Nucleic Acid Synthesis Inhibitors

ClinicalTrials.gov processed this record on January 15, 2009