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Sponsored by: |
Lawson Health Research Institute |
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Information provided by: | Lawson Health Research Institute |
ClinicalTrials.gov Identifier: | NCT00294606 |
This will be a prospective, randomized, double-blinded, cross-over clinical trial to compare the effects of phenylephrine or norepinephrine on cardiac function during carotid artery surgery in patients under general anesthesia. The effect of the vasopressor on cardiac function will be measured using electrocardiography, transesophageal echocardiography and cardiac troponin I intraoperatively and postoperatively. We will use a cross-over pattern since both drugs exhibit rapid onset and short duration of action. We hypothesize that there will be less myocardial ischemia associated with the use of norepinephrine when compared with phenylephrine during carotid artery surgery.
Condition | Intervention |
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Vasopressor Agents Endarterectomy, Carotid Echocardiography, Transesophageal |
Drug: Comparison of Effects of Phenylephrine and Norepinephrine |
Study Type: | Interventional |
Study Design: | Randomized, Double-Blind, Active Control, Crossover Assignment |
Official Title: | Comparison of the Effects of Phenylephrine and Norepinephrine on Cardiac Function During Carotid Cross-Clamping During Carotid Endarterectomy Under General Anesthesia |
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Rosemary A Craen, MD, FRCPC | (519) 663-3022 | rosemary.craen@lhsc.on.ca |
Contact: Hélène G Pellerin, MD, FRCPC | (519) 663-3022 | hpelleri@uwo.ca |
Canada, Ontario | |
University Hospital, LHSC | Recruiting |
London, Ontario, Canada, N6A 5A5 | |
Contact: Rosemary A Craen, MD, FRCPC (519) 663-3022 Rosemary.Craen@lhsc.on.ca | |
Principal Investigator: Rosemary A Craen, MD, FRCPC |
Principal Investigator: | Rosemary A Craen, MD, FRCPC | Associate Professor University of Western Ontario |
Study ID Numbers: | R-05-941 |
Study First Received: | February 17, 2006 |
Last Updated: | February 17, 2006 |
ClinicalTrials.gov Identifier: | NCT00294606 |
Health Authority: | Canada: Health Canada |
vasopressor agents carotid endarterectomy cardiac function transesophageal echocardiography wall motion abnormalities |
Pseudoephedrine Naphazoline Oxymetazoline Guaifenesin Phenylephrine |
Norepinephrine Ephedrine Phenylpropanolamine Congenital Abnormalities |
Respiratory System Agents Neurotransmitter Agents Adrenergic alpha-Agonists Adrenergic Agents Molecular Mechanisms of Pharmacological Action Sympathomimetics Cardiotonic Agents Physiological Effects of Drugs Cardiovascular Agents Protective Agents Adrenergic Agonists |
Pharmacologic Actions Nasal Decongestants Anti-Obesity Agents Mydriatics Autonomic Agents Expectorants Therapeutic Uses Vasoconstrictor Agents Appetite Depressants Peripheral Nervous System Agents Central Nervous System Agents |