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Sponsors and Collaborators: |
Shalvata Mental Health Center Bar-Ilan University, Israel |
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Information provided by: | Shalvata Mental Health Center |
ClinicalTrials.gov Identifier: | NCT00894296 |
The objective of the suggested study is to identify changes in MEG correlates caused by the add-on treatment with the changes in negative symptoms of schizophrenia by comparing the change in the MEG correlates of the subjects before and during usage of new add on treatments for negative symptoms. The investigators hypothesize that the gravity of negative symptoms will correlate with a trend towards more aberrant electroencephalographic correlates mainly in continuous parameters, with an emphasis on alpha and delta bands
Study Type: | Observational |
Study Design: | Case Control, Prospective |
Official Title: | Magnetoencephalographic (MEG) Correlates of Negative Symptoms in Patients Suffering From Schizophrenia and Their Influence by Add-on Treatments |
Estimated Enrollment: | 50 |
Study Start Date: | March 2009 |
Estimated Study Completion Date: | December 2011 |
Estimated Primary Completion Date: | December 2011 (Final data collection date for primary outcome measure) |
Groups/Cohorts |
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1
schizophrenia patients
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2
healthy control
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There is a paucity of information regarding electrophysiological correlates of negative symptoms in patients suffering from schizophrenia. The proposed study is set out to compare the MEG correlates of negative symptoms in patients suffering from schizophrenia to those of healthy controls in terms of both relevant ERP components and quantified (continuous) MEG. The presented study will include two parts: Part A will explore the electrophisological correlates of negative symptoms in patients suffering from schizophrenia using MEG. The study will do so by comparing the electrophisological correlates of schizophrenia patients suffering from negative symptoms and stable on psychiatric treatment to those of healthy controls. In the second part of the study data from part A of patients that have started new add-on treatments for negative symptoms will be compared to parallel data acquired after stabilization on the new treatment.
Ages Eligible for Study: | 18 Years to 65 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
schizophrenia patients and healthy subjects between the ages 18-65
Inclusion Criteria:
The diagnosis will be reaffirmed according to ICD criteria.
Inclusion criteria:
Exclusion Criteria:
Contact: Liron Rabani, MA | 972-97478644 ext 09 |
Israel | |
Bar-Ilan University | Recruiting |
Givat Shmuel, Israel | |
Contact: Liron Rabani, MA 7478644 ext 09 | |
Principal Investigator: Yechiel Levkovitz, MD |
Responsible Party: | Cognitive Lab, Shalvata MHC ( Liron Rabani ) |
Study ID Numbers: | 0027-08-SHA |
Study First Received: | May 5, 2009 |
Last Updated: | May 5, 2009 |
ClinicalTrials.gov Identifier: | NCT00894296 History of Changes |
Health Authority: | Israel: Ministry of Health |
MEG schizophrenia negative symptoms |
Schizophrenia Mental Disorders Psychotic Disorders Schizophrenia and Disorders with Psychotic Features |
Schizophrenia Mental Disorders Schizophrenia and Disorders with Psychotic Features |