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Sponsors and Collaborators: |
Massachusetts General Hospital National Cancer Institute (NCI) |
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Information provided by: | National Cancer Institute (NCI) |
ClinicalTrials.gov Identifier: | NCT00471978 |
RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help the study of cancer in the future.
PURPOSE: This clinical trial is analyzing the DNA in blood and tissue samples from patients with lung cancer.
Condition | Intervention |
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Lung Cancer |
Genetic: polymerase chain reaction Genetic: polymorphism analysis Other: laboratory biomarker analysis |
Study Type: | Observational |
Official Title: | Molecular and Genetic Analysis of Lung Cancer |
Estimated Enrollment: | 6800 |
Study Start Date: | September 2005 |
Estimated Primary Completion Date: | April 2009 (Final data collection date for primary outcome measure) |
OBJECTIVES:
OUTLINE: This is a case-control study.
Blood samples are collected from patients and controls. Samples are analyzed by polymerase chain reaction for gene polymorphisms. Genes to be studied include GSTP1, GSTM1, GSTT1, ERCC2, XRCC1, EPHX, NAT-2, p53 gene, CYP1A1, NQO1, MnSOD, and GPX1. Tissue samples collected from patients undergoing surgery and blood samples are archived for future studies.
Patients and controls complete questionnaires about diet, medical history, and occupational/environmental history.
PROJECTED ACCRUAL: A total of 3,400 patients and 3,400 controls will be accrued for this study.
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
DISEASE CHARACTERISTICS:
Patient:
Newly diagnosed lung cancer
Control:
Nonblood-related friend or spouse of the patient
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
United States, Massachusetts | |
Harvard School of Public Health | Recruiting |
Boston, Massachusetts, United States, 02115 | |
Contact: David C. Christiani, MD 617-726-9274 | |
Massachusetts General Hospital | Recruiting |
Boston, Massachusetts, United States, 02114 | |
Contact: Clinical Trials Office - Massachusetts General Hospital 877-726-5130 |
Principal Investigator: | David C. Christiani, MD | Massachusetts General Hospital |
Study ID Numbers: | CDR0000450128, MGH-1999-P-004935/26, MGH-90-7197 |
Study First Received: | May 8, 2007 |
Last Updated: | February 6, 2009 |
ClinicalTrials.gov Identifier: | NCT00471978 History of Changes |
Health Authority: | Unspecified |
non-small cell lung cancer small cell lung cancer pulmonary carcinoid tumor |
Thoracic Neoplasms Carcinoma, Small Cell Respiratory Tract Diseases Lung Neoplasms |
Lung Diseases Non-small Cell Lung Cancer Carcinoid Tumor Carcinoma, Non-Small-Cell Lung |
Thoracic Neoplasms Respiratory Tract Neoplasms Neoplasms Neoplasms by Site |
Respiratory Tract Diseases Lung Neoplasms Lung Diseases |