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Sponsored by: |
National Eye Institute (NEI) |
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Information provided by: | National Institutes of Health Clinical Center (CC) |
ClinicalTrials.gov Identifier: | NCT00471731 |
Women with premature ovarian failure (POF) are at risk for dry eye. In addition, some women with Turner syndrome (TS) report dry eye symptoms. This study will determine how many women with TS have dry eye, compared to women with POF and women without these conditions.
Females 16 years of age and older with TS, POF, or neither of these conditions may be eligible for this study. Participants undergo the following tests and procedures:
Condition |
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Turner Syndrome Ovarian Failure, Premature Sex Chromosome Aberrations Menopause Perimenopause |
Study Type: | Observational |
Study Design: | Prospective |
Official Title: | Ocular Impact of X Chromosome Karyotype and Sex Hormones in Turner Syndrome and Premature Ovarian Failure |
Estimated Enrollment: | 180 |
Study Start Date: | May 2007 |
Premature ovarian failure (POF) is known to be associated with an increased risk of ocular surface disease (dry eye), likely due to the reduction of both estrogens and androgens seen in this condition. From preliminary data, we suspect that women with Turners syndrome (45, XO), a genetic abnormality that affects sex hormone levels, are also at increased risk of ocular surface disease. Comparing POF and TS women may allow us to distinguish different mechanisms for ocular surface disease, due to the different etiologies of hormonal (estrogen and androgen) alterations posed by POF and TS.
Ages Eligible for Study: | 16 Years and older |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | Yes |
INCLUSION CRITERIA:
EXCLUSION CRITERIA:
Contact: Patient Recruitment and Public Liaison Office | (800) 411-1222 | prpl@mail.cc.nih.gov |
Contact: TTY | 1-866-411-1010 |
United States, Maryland | |
National Institutes of Health Clinical Center, 9000 Rockville Pike | Recruiting |
Bethesda, Maryland, United States, 20892 |
Study ID Numbers: | 070145, 07-EI-0145 |
Study First Received: | May 9, 2007 |
Last Updated: | April 17, 2009 |
ClinicalTrials.gov Identifier: | NCT00471731 History of Changes |
Health Authority: | United States: Federal Government |
Ocular Surface Disease Imprinting Eye Abnormalities Ovarian Insufficiency Women's Eye Health and Disease Turner Syndrome |
TS Premature Ovarian Failure POF Healthy Volunteer HV |
Sex Chromosome Aberrations Gonadal Disorders Genital Dwarfism Chromosome Disorders Endocrine System Diseases Ovarian Failure, Premature Healthy Ovarian Diseases Ovarian Dwarfism Hormones Sex Differentiation Disorders |
Monosomy X Eye Abnormalities Turner Syndrome Genital Diseases, Female Urogenital Abnormalities Genetic Diseases, Inborn Chromosome Aberrations Endocrinopathy Congenital Abnormalities Menopause Gonadal Dysgenesis |
Sex Chromosome Aberrations Disease Gonadal Disorders Chromosome Disorders Endocrine System Diseases Ovarian Failure, Premature Ovarian Diseases Sex Differentiation Disorders Adnexal Diseases Turner Syndrome |
Genital Diseases, Female Pathologic Processes Urogenital Abnormalities Genetic Diseases, Inborn Syndrome Chromosome Aberrations Sex Chromosome Disorders Congenital Abnormalities Gonadal Dysgenesis |