Inclusion Criteria:

• 40-75 years old
• Ischemic stroke diagnosed by CT/MRI scan
• Patient presenting from 14 days to 6 months of first onset of Ischemic stroke.
• Presence of at least one risk factor of stroke (such as hypertension, Diabetes mellitus, coronary heart disease, hyperlipidemia, and smoking, etc.)that can be interfered in.
• Informed consent.

Exclusion Criteria:

• Silent cerebral infarction;
• Patients after vasculoplasty with Intracranial Artery Stenosis.
• Watian drinking test≥grade 4.
• MRS=grade 5.
• Cerebral infarction due to other causes except arterial Sclerosis(i.e. cardiogenic embolism, arteritis, polycythemia vera, primary thrombocythemia, sickle-cell anemia,, thrombotic thrombocytopenia purpura, DIC, cerebral amyloid angiopathy, Moyamoya disease, intracranial vascular malformations etc);
• Presence of serious heart disease, heart, liver, lung, and kidney functional failure; malignancy; alimentary tract hemorrhage;
• Patients with mental disorder.
• Patients that cannot take medicine due to other causes
• Females during pregnancy or lactation.
• Already attend other clinical trial.
• That unsuitable for clinical trial.