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| Sponsored by: |
University Hospital, Tours |
|---|---|
| Information provided by: | University Hospital, Tours |
| ClinicalTrials.gov Identifier: | NCT00700232 |
Purpose
Mutations of the ATP binding cassette subfamily B member 4 (ABCB4) gene, a gene involved in a subtype of progressive familial intrahepatic cholestasis, have been reported in women suffering from intrahepatic cholestasis of pregnancy. The true incidence and the role of these ABCB4 gene mutations in patients suffering from intrahepatic cholestasis of pregnancy have not been clearly established.
The aim of the present study is to describe the nature and frequency of these mutations in a series of patients with intrahepatic cholestasis of pregnancy and to compare with a control group of pregnant women without intrahepatic cholestasis of pregnancy.
| Condition |
|---|
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Intrahepatic Cholestasis of Pregnancy |
| Study Type: | Observational |
| Study Design: | Cohort, Prospective |
| Official Title: | Mutations and Polymorphisms of Gene ABCB4 Among Women Suffering From Intrahepatic Cholestasis of Pregnancy. A Study With a Control Group. |
blood samples
| Estimated Enrollment: | 120 |
| Study Start Date: | July 2006 |
| Estimated Study Completion Date: | July 2009 |
| Primary Completion Date: | July 2008 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
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1
Normal multiparous pregnant women without intrahepatic cholestasis of pregnancy (control group)
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Intrahepatic cholestasis of pregnancy was defined by pruritus and elevated serum alanine aminotransferase activity or bile acid concentration, with recovery after delivery. Patients with intercurrent liver disease were excluded.
The entire ABCB4 gene coding sequence and the promoter region were analyzed, during the routine medical management, by single strand conformation polymorphism and/or sequencing in 50 unrelated Caucasian patients with intrahepatic cholestasis of pregnancy.
The genomic variants detected in these patients with intrahepatic cholestasis of pregnancy will be sought in 100 control women from Caucasian origin recruited in the same hospital.
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Female |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
multiparous normal pregnant women (control group)from a single University center
For the control group :
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| France | |
| Service de Gynécologie Obstétrique CHRU Tours | |
| TOURS, France, 37044 | |
| Study Director: | BACQ Yannick, MD | Service d'hépato-gastro-entérologie CHRU Tours |
More Information
| Responsible Party: | University Hospital, Tours ( University Hospital, Tours ) |
| Study ID Numbers: | AOHP06-YB GEN CIG |
| Study First Received: | June 13, 2008 |
| Last Updated: | February 12, 2009 |
| ClinicalTrials.gov Identifier: | NCT00700232 History of Changes |
| Health Authority: | France: Ministry of Health |
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genetics gene expression MDR3 estrogens |
cholestasis pregnancy controls |
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Estrogens Liver Diseases Digestive System Diseases Cholestasis, Intrahepatic |
Bile Duct Diseases Cholestasis Biliary Tract Diseases |
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Liver Diseases Digestive System Diseases Cholestasis, Intrahepatic |
Bile Duct Diseases Cholestasis Biliary Tract Diseases |
