Inclusion Criteria:

• Vitiligo patients aged 18 years and older
• Vitiligo patients with evaluable lesions; duration of 3 months to 10 years.
• Disease interferes significantly with quality of life and/or involving 3% or more body surface area
• Subjects must have a negative tuberculin (TB) skin test at entry into the study
• If subject is a female of childbearing potential, she must agree to use adequate contraception (adequate contraception can include abstinence) and must have a negative serum pregnancy test the day of administration of study medication.
• If subject is a male and has reached puberty, he must agree to use adequate contraception during the study and for 1 month after discontinuation from study.
• Subject or designee must have the ability to self-inject investigational product or have a care giver at home who can administer subcutaneous injections
• Subject must be able to give informed consent; must authorize release and use of protected health information; and, if applicable, must assent to participate prior to enrollment to this study.

Exclusion Criteria:

• Unable to consent
• History of non-compliance with other therapies
• Concurrent therapy for vitiligo
• Systemic or photo-therapy within 4 weeks
• Topical therapy within 2 weeks
• Any medical condition in which etanercept would be contraindicated
• Any internal malignancy within 5 years (fully excised cutaneous, basal cell carcinoma or squamous cell carcinoma are exceptions)
• Pregnancy, not practicing effective birth control, or inability to practice safe sex during the length of the study.
• Lactation
• History of alcohol or drug abuse one year before and during the study.
• Any participation in another investigational drug study during the 4 weeks preceding this study.
• Known HIV-positive status; known history of any other mycobacterial disease or any other immuno-suppressing disease.
• Presence of a grade 3 or 4 infection < 30 days prior to the screening visit; between the screening visit and the first day of treatment on study; or any time during the study that, in the opinion of the Investigator, would preclude participation in the study.
• Patients should not receive live vaccines for 3 months prior to, or while on, study.
• A prior history of tuberculosis, and/or a positive PPD skin test and positive CXR at screening.

• Patients with previous or current exposure to any of the following TNF antagonists:

  • etanercept (Enbrel);
  • adalimumab (Humira); or
  • infliximab (Remicade).

These patients will not be eligible, even with a wash-out. Patients with previous or current exposure to Kineret will NOT be eligible, even with a wash-out. However, patients with prior or current exposure to biologics directed against T-cells (e.g. alefacept, efalizumab, siplizumab, etc.) will be eligible for enrollment into the study after a wash-out period of 4 weeks before first dose of study drug (baseline visit). It has to be protocol specific also.

• The subject has, in the Investigator's opinion, a chronic, severe, progressive, or uncontrolled renal, hepatic, hematological, gastrointestinal, pulmonary, cardiovascular (congestive heart failure [CHF] of any severity; myocardial infarction [MI], cerebrovascular accident [CVA] or transient ischemic attack [TIA] within 3 months of screening visit; unstable angina pectoris; uncontrolled hypertension [sitting systolic blood pressure (BP) < 80 mm Hg or > 160 or diastolic BP > 100 mm Hg]), or neurological disease; known systemic lupus erythematosus (SLE); diabetes; or any other concomitant medical condition that places the participant at risk by participating this study and/or that may interfere with the conduct of the study.
• Chronic hepatitis B or hepatitis C, SLE, history of multiple sclerosis, transverse myelitis, optic neuritis or epilepsy.