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Sponsored by: |
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
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Information provided by: | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
ClinicalTrials.gov Identifier: | NCT00618475 |
Depression is second in frequency only to hypertension as a comorbid condition for End Stage Renal Disease (ESRD) patients. The presence of depression has been linked to lower quality of life, more medical comorbidities and shorter lifespan. This project represents the first known attempt at a standardized intervention for depression in ethnically diverse ESRD patients. The study will be conducted at the Parkside Center for Dialysis. Patients will be randomly selected for screening until 80 subjects meet entry criteria and agree to be randomized. Once subjects are screened and enrolled in the study they are randomly assigned to either a treatment or wait-list control condition. After 3 months, the intervention will be completed and both groups will be reassessed. After an additional 3 months, both groups will have received the intervention and pre and post measures for both groups will be available as well as 3 month follow-up for the 1st intervention group. The following measures will be collected: to obtain a full DSM-IV diagnosis the SCID I and SCID II will be utilized. The BDI will provide a self-report measure of depression. The Hospital Anxiety and Depression Scale (HADS), a measure designed specifically for medically ill patients, will also be administered. Additionally, the Young Schema Questionnaire, a measure which seeks to identify maladaptive (both depressive and anxious) cognitive styles, will be administered. A quality of life measure designed specifically for dialysis patients (KDQOL-SF) will also be given as a means of measuring patient's overall coping and functioning. To better understand the patient's perceptions of their health and illness the Illness Effects Questionnaire will be administered. A demographic information sheet will be completed by the subject in which personal, ethnic, and illness information is collected. Detailed information about the subject's mental health history and treatment as well as current medications will be gathered. Data from routine dialysis laboratories (hemoglobin, creatinine, albumin, Kt/V) will be extracted from the chart.
The intervention will take place in individual format while the subjects are being dialyzed. The intervention will be 10 sixty minute -long weekly sessions spread over not more than 3 months. It will include both cognitive and behavioral skills focused on alleviating depressive affect and identifying maladaptive patterns of thought and behavior. This study would lay the groundwork for future clinical research by helping to develop a culturally competent clinical intervention and demonstrate the feasibility and effectiveness of adapting psychosocial intervention for a medically complex culturally diverse population.
Condition | Intervention |
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End Stage Renal Disease Depression |
Behavioral: Cognitive behavioral therapy |
Study Type: | Observational |
Study Design: | Case-Crossover, Prospective |
Estimated Enrollment: | 80 |
Study Start Date: | August 2008 |
Estimated Study Completion Date: | August 2012 |
Estimated Primary Completion Date: | August 2011 (Final data collection date for primary outcome measure) |
Groups/Cohorts | Assigned Interventions |
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1
Intervention
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Behavioral: Cognitive behavioral therapy
10 sessions 1 hour per week
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2
wait-list control
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Behavioral: Cognitive behavioral therapy
10 sessions 1 hour per week
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Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Probability Sample |
ESRD patients treated with hemodialysis
Inclusion Criteria:
- hemodialysis patient Depression diagnosis
Exclusion Criteria:
(1) presence of current organic mental disorder (2) schizophrenia (3) bipolar disorder (4) depression with psychotic features (5) current substance abuse or dependence (6) active suicidal intent or plan (7) active homicidal ideation, intent, or plan -
Contact: Daniel Cukor, PhD | (718)270-2077 | daniel.cukor@downstate.edu |
United States, New York | |
Parkside Hemodialysis | Recruiting |
Brooklyn, New York, United States, 11203 | |
Principal Investigator: Daniel Cukor, PhD |
Principal Investigator: | Daniel Cukor, PhD. | State University of New York - Downstate Medical Center |
Responsible Party: | SUNY Downstate Medical Center ( Daniel Cukor PhD ) |
Study ID Numbers: | DK76980 |
Study First Received: | February 15, 2008 |
Last Updated: | February 26, 2009 |
ClinicalTrials.gov Identifier: | NCT00618475 History of Changes |
Health Authority: | United States: Federal Government |
Depression End Stage Renal Disease Kidney Disease Mental Health |
Renal Insufficiency Depression Urologic Diseases Renal Insufficiency, Chronic Mental Disorders Mood Disorders |
Kidney Failure, Chronic Kidney Diseases Depressive Disorder Behavioral Symptoms Kidney Failure |
Renal Insufficiency Depression Urologic Diseases Renal Insufficiency, Chronic Mental Disorders Mood Disorders |
Kidney Failure, Chronic Kidney Diseases Depressive Disorder Kidney Failure Behavioral Symptoms |