Inert Dusts and Pathology of Chronic Obstructive Pulmonary Disease

This study is ongoing, but not recruiting participants.

First Received: February 5, 2008 Last Updated: February 4, 2009 History of Changes

Sponsored by:	Medical University of Vienna
Information provided by:	Medical University of Vienna
ClinicalTrials.gov Identifier:	NCT00618137

Purpose

The main objective of the study is the exploration of the natural course of COPD and its biological background. To this end, active workers without COPD and workers in functional classes GOLD 0-III are investigated by a combined clinical and molecular approach. The study has been designed as a prospective, intraindividual pilot in 160 male or female volunteers of the greater Vienna Area over a period of three years for each individual volunteer.

Condition
Pulmonary Disease, Chronic Obstructive

MedlinePlus related topics: COPD (Chronic Obstructive Pulmonary Disease)

U.S. FDA Resources

Study Type:	Observational
Study Design:	Cohort, Prospective
Official Title:	Longitudinal Assessment of Clinical and Molecular Pathology of Chronic Obstructive Lung Disease and the Possible Influence of Inert Dusts in Working Volunteers of the Greater Vienna Area

Further study details as provided by Medical University of Vienna:

Biospecimen Retention: Samples With DNA

Biospecimen Description:

Transbronchial lung biopsies Blood serum

Estimated Enrollment:	160
Study Start Date:	January 2007
Estimated Study Completion Date:	December 2011
Estimated Primary Completion Date:	December 2011 (Final data collection date for primary outcome measure)

Show Detailed Description

Eligibility

Ages Eligible for Study:	18 Years to 65 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes
Sampling Method:	Probability Sample

Study Population

Community sample of workers from the greater Vienna area

Criteria

Inclusion Criteria:

COPD °0-III
Workers of the greater Vienna Area
Current smokers or ex-smokers

Exclusion Criteria:

COPD °IV
Bronchial asthma
Major cardiovascular diseases, in particular stroke and myocardial infarction with reduced cardiac function
Age > 65 years
Acute or chronic bronchial infection, in particular bronchiectasis
Cancer

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00618137

Locations

Austria
Department of Pulmonary Medicine, Medical University of Vienna
Vienna, Austria, A-1090

Sponsors and Collaborators

Medical University of Vienna

Investigators

Principal Investigator:	Lutz H Block, MD	Medical University of Vienna
Study Director:	Rolf Ziesche, MD	Medical University of Vienna

More Information

No publications provided

Responsible Party:	Medical University of Vienna ( Prof. Dr. Lutz-Henning Block )
Study ID Numbers:	COPD-AUVA
Study First Received:	February 5, 2008
Last Updated:	February 4, 2009
ClinicalTrials.gov Identifier:	NCT00618137 History of Changes
Health Authority:	Austria: Ethikkommission; Austria: Study Board of the Austrian Social Compensation Insurance

Keywords provided by Medical University of Vienna:

Chronic obstructive pulmonary disease
Gene expression profiling
Inert dusts
Natural course
Prospective assessment

Study placed in the following topic categories:

Lung Diseases, Obstructive
Respiratory Tract Diseases
Lung Diseases

Respiration Disorders
Chronic Disease
Pulmonary Disease, Chronic Obstructive

Additional relevant MeSH terms:

Disease Attributes
Lung Diseases, Obstructive
Pathologic Processes
Respiratory Tract Diseases

Lung Diseases
Respiration Disorders
Chronic Disease
Pulmonary Disease, Chronic Obstructive

ClinicalTrials.gov processed this record on May 07, 2009