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Sponsored by: |
Bangalore Assisted Conception Centre |
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Information provided by: | Bangalore Assisted Conception Centre |
ClinicalTrials.gov Identifier: | NCT00796341 |
Implantation of the human embryo is the limiting factor in the success of invitro-fertilization and embryo transfer(IVF-ET).We wanted to find out whether creating a local injury to the endometrium in the non-transfer cycle would improve the IVF-ET outcome in the subsequent cycle.We believe that the injury created causes release of substances which help in implantation.
Condition | Intervention |
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Infertility |
Procedure: PIPELLE ENDOMETRIAL SAMPLING |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Open Label, Active Control, Single Group Assignment |
Official Title: | Does Endometrial Injury in the Non-Transfer Cycle Improve the IVF-ET Outcome in the Subsequent Cycle in Patients With Previous Failed IVF Cycles: A Randomized Control Trial |
Enrollment: | 99 |
Study Start Date: | November 2007 |
Study Completion Date: | September 2008 |
Primary Completion Date: | September 2008 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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1: Experimental |
Procedure: PIPELLE ENDOMETRIAL SAMPLING
Pipelle endometrial sampling will be done twice between 7th to 10th day and 24th to 26th d in the cycle prior to IVF.
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2: No Intervention |
Study Design and Subjects: This is a randomized control study designed to evaluate the effect of local injury to the endometrium in non-transfer cycle in patients with previous failed IVF.
Patients will be randomly allotted to control and intervention group The patients in the intervention group Pipelle endometrial sampling 7-10th day and 24-26th day in the cycle prior to IVF transfer cycle.
Outcome Measures: Clinical pregnancy rate,implantation rate and ongoing pregnancy rate.
SAMPLE SIZE: 100 PATIENTS (50 in each group).
Ages Eligible for Study: | 18 Years to 37 Years |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
India, KARNATAKA | |
Bangalore Assisted Conception Centre | |
BANGALORE, KARNATAKA, India, 560001 |
Principal Investigator: | SACHIN A NARVEKAR, MD | Bangalore Assisted Conception Centre |
Responsible Party: | Bangalore Assisted Conception Centre ( Dr Kamini A Rao ) |
Study ID Numbers: | endometrial injury study |
Study First Received: | November 21, 2008 |
Last Updated: | December 1, 2008 |
ClinicalTrials.gov Identifier: | NCT00796341 History of Changes |
Health Authority: | India: Institutional Review Board |
invitro-fertilization ,embryo transfer,endometrial injury |
Genital Diseases, Female Infertility Genital Diseases, Male |
Genital Diseases, Female Infertility Genital Diseases, Male |