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Sponsors and Collaborators: |
Massachusetts General Hospital Forest Laboratories |
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Information provided by: | Massachusetts General Hospital |
ClinicalTrials.gov Identifier: | NCT00116532 |
The purpose of this study is to assess the efficacy of Escitalopram in the treatment of obsessive compulsive disorder and to determine the optimal treatment dose.
Condition | Intervention | Phase |
---|---|---|
Obsessive Compulsive Disorder |
Drug: Escitalopram |
Phase IV |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Open Label, Dose Comparison, Parallel Assignment, Efficacy Study |
Official Title: | Escitalopram for the Treatment of Obsessive Compulsive Disorder |
Estimated Enrollment: | 30 |
Study Start Date: | October 2002 |
Study Completion Date: | February 2007 |
Background and Purpose: Obsessive compulsive disorder affects approximately 3% of the population. Treatment options include the selective serotonin reuptake inhibitors (SSRIs), dual serotonin and norepinephrine reuptake inhibitors, and behavioral therapy. A recent double-blind, placebo-controlled trial demonstrated that citalopram is effective in the treatment of OCD. Escitalopram is a new SSRI that may be more effective than other SSRIs for the treatment of major depression and may have fewer side effects. This study aims to assess the efficacy of escitalopram for the treatment of OCD.
Comparisons: Subject Y-BOCs pre-post treatment. We will also compare the improvement of subjects across the three different medication levels: 10 mg, 20 mg, and 30 mg.
Ages Eligible for Study: | 18 Years to 65 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
United States, Massachusetts | |
Massachusetts General Hospital - OCD Clinic | |
Charlestown, Massachusetts, United States, 02129 |
Principal Investigator: | Darin D Dougherty, MD | Massachusetts General Hospital |
Study ID Numbers: | 2002-P-000895, LXP-MD-14, 1200-211220 |
Study First Received: | June 29, 2005 |
Last Updated: | April 23, 2007 |
ClinicalTrials.gov Identifier: | NCT00116532 History of Changes |
Health Authority: | United States: Institutional Review Board |
Obsessive Compulsive Disorder Escitalopram SSRI Open Label |
Neurotransmitter Agents Cholinergic Antagonists Psychotropic Drugs Cholinergic Agents Citalopram Serotonin Uptake Inhibitors Serotonin Muscarinic Antagonists |
Anxiety Disorders Mental Disorders Peripheral Nervous System Agents Dexetimide Antidepressive Agents, Second-Generation Obsessive-Compulsive Disorder Antidepressive Agents |
Parasympatholytics Neurotransmitter Uptake Inhibitors Neurotransmitter Agents Cholinergic Antagonists Molecular Mechanisms of Pharmacological Action Anti-Dyskinesia Agents Physiological Effects of Drugs Psychotropic Drugs Antiparkinson Agents Cholinergic Agents Pathologic Processes Mental Disorders Therapeutic Uses Dexetimide |
Antidepressive Agents, Second-Generation Obsessive-Compulsive Disorder Antidepressive Agents Disease Citalopram Serotonin Uptake Inhibitors Pharmacologic Actions Muscarinic Antagonists Serotonin Agents Anxiety Disorders Autonomic Agents Peripheral Nervous System Agents Central Nervous System Agents |