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Sponsored by: |
University Health Network, Toronto |
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Information provided by: | University Health Network, Toronto |
ClinicalTrials.gov Identifier: | NCT00496249 |
Many younger men are diagnosed with prostate cancer. These patients are often choosing radiation therapy as their primary treatment. The effect of this therapy on fertility will have a direct impact on their decision about therapeutic options and fertility preservation. The researchers hypothesize that when patients are treated with radiation for localized prostate cancer, infertility can occur due to direct damage to seminiferous tubules affecting sperm quality.
Condition |
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Prostate Cancer |
Study Type: | Observational |
Study Design: | Screening, Longitudinal, Defined Population, Prospective Study |
Official Title: | The Effect of Radiation on Semen Quality and Fertility in Men Treated With External Beam Radiation or Brachytherapy for Early Stage Prostate Cancer |
Estimated Enrollment: | 40 |
Study Start Date: | July 2007 |
Estimated Study Completion Date: | January 2008 |
Prostate cancer is the most common malignant disease among men. Many young men are diagnosed with localized prostate cancer. Some of these men are choosing to manage their prostate cancer with radiation therapy. The radiation therapy delivers minimal dose exposure to adjacent organs. We hypothesize that when patients are treated with radiation therapy for localized prostate cancer, decreased fertility can occur due to damage of seminiferous tubules, which may affect sperm quality. This study will assess the impact of radiation therapy on semen and seminal fluid.
Ages Eligible for Study: | 18 Years to 55 Years |
Genders Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: Sally Fairbairn, BSc | 416 946 4501 ext 3832 | sally.fairbairn@uhn.on.ca |
Contact: Karen Hersey, RN | 416 946 2155 | karen.hersey@uhn.on.ca |
Canada, Ontario | |
University Health Network | |
Toronto, Ontario, Canada, M5G 2M9 |
Principal Investigator: | Neil Fleshner, MD | University Health Network, Toronto |
Study ID Numbers: | 07-0197-CE |
Study First Received: | July 3, 2007 |
Last Updated: | July 3, 2007 |
ClinicalTrials.gov Identifier: | NCT00496249 History of Changes |
Health Authority: | Canada: Ethics Review Committee |
Prostate cancer brachytherapy |
radiation semen fertility |
Infertility Prostatic Diseases Genital Neoplasms, Male |
Urogenital Neoplasms Genital Diseases, Male Prostatic Neoplasms |
Neoplasms Neoplasms by Site Prostatic Diseases Genital Neoplasms, Male |
Urogenital Neoplasms Genital Diseases, Male Prostatic Neoplasms |