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Sponsored by: |
Baycrest |
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Information provided by: | Baycrest |
ClinicalTrials.gov Identifier: | NCT00643266 |
We have developed a training intervention that successfully improves older adults' memory. We have also shown that older adults whose memory is as good as younger adults' memory (Hi-Old) use an altered pattern of memory-related brain activity compared to younger adults, whereas healthy older adults with poorer memory (Lo-Old) do not. We have also shown that individuals with amnestic Mild Cognitive Impairment (aMCI) have impairments of conscious, effortful, Recollection-based memory processes, whereas their automatic, Familiarity-based memory processes are intact. Our primary current goal is to investigate whether our successful memory intervention will improve Recollection and produce induce altered patterns of brain activity in the Lo-Old and aMCI.
Young, Lo-Old, Hi-Old, and aMCI will be scanned using functional magnetic resonance imaging while performing two memory tasks. Half of the Lo-Old and half of the aMCI will then receive the memory intervention, while the other half in each group will receive a control program consisting of information and games about aging. The Lo-Old and aMCI will then be rescanned while performing the two memory tasks. We predict that the memory intervention will improve performance on a number of memory tasks, and will induce altered patterns of brain activity. In the Lo-Old, their brain activity after the memory intervention will look more like the Hi-Old, while brain activity will become more focal in the aMCI.
Condition | Intervention |
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Amnestic Mild Cognitive Impairment Aging |
Behavioral: Recollection Training Behavioral: Control |
Study Type: | Interventional |
Study Design: | Basic Science, Non-Randomized, Single Blind (Investigator), Parallel Assignment, Efficacy Study |
Official Title: | Memory Interventions for Older Adults |
Estimated Enrollment: | 80 |
Study Start Date: | February 2008 |
Estimated Study Completion Date: | March 2011 |
Estimated Primary Completion Date: | March 2010 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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1: Experimental
Recollection training via graduated increases in task difficulty, carried out over 36 sessions over 9 training days
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Behavioral: Recollection Training
Participants are exposed to long lists of words. Each word is presented either visually or auditorily, and each word is repeated after a variable number of intervening words (the lag), in each the same modality, or the other modality. Participants are instructed to respond "yes" only to words repeated in the same modality. If a performance criterion is met, the lag is increased for the next session; if the performance criterion is not met, the same lag is repeated in the next session.
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2: Active Comparator
Computer-delivered information sessions about memory and aging with Jeopardy-like games to engage participants
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Behavioral: Control
Participants view PowerPoint presentations on various topics related to memory and aging (e.g., structural brain changes, diet, stress, depression) and how each of these topics affect memory, and after each presentation, play a Jeopardy-like game to test their knowledge gain
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Ages Eligible for Study: | 18 Years to 90 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: Nicole D Anderson, PhD, CPsych | 416-785-2500 ext 3366 | nanderson@klaru-baycrest.on.ca |
Canada, Ontario | |
Baycrest | Recruiting |
Toronto, Ontario, Canada, M6A 2E1 | |
Contact: Nicole D Anderson, PhD, CPsych 416-785-2500 ext 3366 nanderson@klaru-baycrest.on.ca | |
Principal Investigator: Nicole D Anderson, PhD, CPsych |
Principal Investigator: | Nicole D Anderson, PhD, CPsych | Baycrest |
Responsible Party: | Baycrest ( Dr. Nicole Anderson ) |
Study ID Numbers: | RecollectionTraining, CIHR MOP 67015, ASC 08 95 |
Study First Received: | February 26, 2008 |
Last Updated: | March 24, 2008 |
ClinicalTrials.gov Identifier: | NCT00643266 History of Changes |
Health Authority: | Canada: Canadian Institutes of Health Research |
recollection training aging amnestic mild cognitive impairment fMRI |
Delirium, Dementia, Amnestic, Cognitive Disorders Mental Disorders Healthy |
Dementia Cognition Disorders Delirium |
Delirium, Dementia, Amnestic, Cognitive Disorders Mental Disorders Cognition Disorders |