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Sponsored by: |
National Institute of Neurological Disorders and Stroke (NINDS) |
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Information provided by: | National Institutes of Health Clinical Center (CC) |
ClinicalTrials.gov Identifier: | NCT00039819 |
This study will determine whether stimulating the nerves or the brain can modify the spinal reflex that controls the muscles that flex and extend the ankle. Training spinal nerve networks with sensory input may provide a way of re-establishing movements, such as walking, in patients with spinal injury.
Healthy normal volunteers with no history of peripheral neuropathy or radiculopathy, ankle contractures or tendon surgery may be eligible for this study. Participants will undergo three stimulation procedures, each in a different session, to measure leg muscle reflexes. The procedures are:
The strength of the stimulus is adjusted to produce little or no muscle movement. The stimulation is repeated every few seconds for 45 minutes.
Condition |
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Healthy |
Study Type: | Observational |
Official Title: | Plasticity of Reciprocal Inhibition |
Estimated Enrollment: | 25 |
Study Start Date: | June 2002 |
Estimated Study Completion Date: | May 2003 |
Training of spinal interneuronal networks may offer a means for re-establishing movements such as locomotion in patients with spinal injury. Sensory feedback in the pattern which results from the leg movement is hypothesized to be the critical component for training spinal networks. This protocol will address the basic assumption underlying such training: can a specific pattern of sensory input modify the strength of a spinal cord circuit? We will test whether peripheral nerve stimulation can modify the strength of the spinal reflex mediating reciprocal inhibition between ankle flexor and extensor muscles in normal subjects, comparing patterned and unpatterned stimulation.
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
INCLUSION CRITERIA:
Healthy adult volunteers willing to participate
EXCLUSION CRITERIA:
History of peripheral neuropathy or radiculopathy
Implanted devices, including pacemakers, pumps, and defibrillators
Ankle contractures or tendon surgery
Study ID Numbers: | 020228, 02-N-0228 |
Study First Received: | June 11, 2002 |
Last Updated: | March 3, 2008 |
ClinicalTrials.gov Identifier: | NCT00039819 History of Changes |
Health Authority: | United States: Federal Government |
Spinal Cord Sensory Stimulation Locomotion Magnetic Stimulation |
Reflexes Healthy Volunteer HV Normal Control |
Healthy |