The Combined Effect of 2,3-Dimercaptosuccinic Acid and Multi-Nutrients on Children in Lead Poisoning

This study has been completed.

First Received: September 11, 2006 No Changes Posted

Sponsored by:	China Medical University, China
Information provided by:	China Medical University, China
ClinicalTrials.gov Identifier:	NCT00374894

Purpose

Lead poisoning remains a common disease among children despite successful public health efforts that reduced its prevalence.Our study was designed to test the hypothesis that lead-poisoning children (BLLs:100-440µg/L) who were given DMSA and multi-nutrients would have a greater fall than children of other groups at 12 weeks of follow-up.

Condition	Intervention
Lead Poisoning	Drug: 2,3-dimercaptosuccinic acid

MedlinePlus related topics: Lead Poisoning Poisoning

Drug Information available for: Succimer

U.S. FDA Resources

Study Type:	Observational
Study Design:	Screening, Longitudinal, Defined Population, Prospective Study

Further study details as provided by China Medical University, China:

Estimated Enrollment:	500
Study Start Date:	March 2004
Estimated Study Completion Date:	August 2004

Eligibility

Ages Eligible for Study:	3 Years to 6 Years
Genders Eligible for Study:	Both

Criteria

Inclusion Criteria:

Initial BLLs 100-440µg/L
Age 3-6y
No more than two main residences
House cleaned (no lead contaminated)
Normal intake history and physical

Exclusion Criteria:

Chelation in the past 12 weeks
Concomitant Fe deficiency(ferritin<16ng/ml)
Hemoglobin<10.5g/dL
Medications affecting mineral metabolism

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00374894

Locations

China, Liaoning
China Medical University
Shenyang, Liaoning, China, 110001

Sponsors and Collaborators

China Medical University, China

Investigators

Study Director:

Jin Ya ping, professor

Department of Environmental and Occupational Health

More Information

No publications provided

Study ID Numbers:	20032063 - 2001102049
Study First Received:	September 11, 2006
Last Updated:	September 11, 2006
ClinicalTrials.gov Identifier:	NCT00374894 History of Changes
Health Authority:	China: Ministry of Health

Keywords provided by China Medical University, China:

2,3-dimercaptosuccinic acid
Blood Lead Levels
children
multi-nutrients

Study placed in the following topic categories:

Succimer
Lead Poisoning
Poisoning
Disorders of Environmental Origin
Chelating Agents

Additional relevant MeSH terms:

Succimer
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Poisoning
Lead Poisoning

Disorders of Environmental Origin
Chelating Agents
Protective Agents
Pharmacologic Actions
Antidotes

ClinicalTrials.gov processed this record on May 07, 2009