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Sponsored by: |
National Institute of Mental Health (NIMH) |
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Information provided by: | National Institute of Mental Health (NIMH) |
ClinicalTrials.gov Identifier: | NCT00045903 |
This study will evaluate the effectiveness of two cognitive behavioral therapies (CBTs) in treating obsessive compulsive disorder (OCD) in patients who are taking medication but still have residual symptoms.
Condition | Intervention |
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Obsessive-Compulsive Disorder |
Behavioral: Exposure and Ritual Prevention (Cognitive Behavioral Therapy) Behavioral: Stress Management Therapy (Cognitive Behavior Therapy) |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Single Blind, Active Control, Parallel Assignment, Efficacy Study |
Official Title: | CBT Augmentation for SRI Pharmacotherapy in OCD |
Estimated Enrollment: | 136 |
Study Start Date: | August 2000 |
Study Completion Date: | January 2007 |
Participants remain on their current OCD medication and are randomly assigned to receive one of two CBTs: exposure and ritual prevention or stress management therapy. Exposure and ritual prevention involves imaginal and in-vivo exposure and requires that participants refrain from ritualizing. Stress management involves relaxation, assertiveness training, and structured problem-solving. Therapy occurs twice per week for 2 months. Participants are assessed verbally by an independent evaluator and are asked to complete self-rating forms. Patients who respond are followed for up to 1 additional year.
Participants continue to take the same medication and the same monthly therapy for the first 6 months of follow-up. During the second 6 months of follow-up, participants discontinue therapy but continue taking the same medication.
For information on a related study, please follow this link:
http://clinicaltrials.gov/show/NCT00389493
Ages Eligible for Study: | 18 Years to 70 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
United States, New York | |
New York State Psychiactic Institute, Anxiety Disorders Clinic | |
New York, New York, United States, 10032 | |
United States, Pennsylvania | |
University of Pennsylvania Center for the Treatment and Study of Anxiety | |
Philadelphia, Pennsylvania, United States, 19104 |
Principal Investigator: | Michael Liebowitz, MD | New York State Psychiatric Institute |
Principal Investigator: | Edna Foa, MD | University of Pennsylvania |
Study ID Numbers: | R01 MH045436-01, DSIR AT-CT |
Study First Received: | September 13, 2002 |
Last Updated: | February 19, 2009 |
ClinicalTrials.gov Identifier: | NCT00045903 History of Changes |
Health Authority: | United States: Federal Government |
Cognitive Behavioral Therapy |
Anxiety Disorders Mental Disorders Obsessive-Compulsive Disorder |
Pathologic Processes Disease Anxiety Disorders Mental Disorders Obsessive-Compulsive Disorder |