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Sponsored by: |
Samsung Medical Center |
---|---|
Information provided by: | Samsung Medical Center |
ClinicalTrials.gov Identifier: | NCT00767754 |
Panic disorder is one of the most prevalent and disabling psychiatric disorders. Brain regions such as amygdala, hippocampus, periaqueductal gray (PAG), locus coeruleus, parahippocampal gyrus, frontal cortex, and thalamus has been reported to be related with the pathophysiology and treatment outcome in panic disorder. Paroxetine has been used as primary agent for treatment of panic disorder but there is little information on how paroxetine affects the brain function in patients with panic disorder. The specific aim of this study is to examine the differences in brain activity between responders and nonresponders and to determine the predictor of paroxetine treatment in patients with panic disorder in terms of brain activity.
Condition | Intervention | Phase |
---|---|---|
Panic Disorder |
Drug: Paxil CR |
Phase IV |
Study Type: | Interventional |
Study Design: | Treatment, Open Label, Uncontrolled, Single Group Assignment |
Estimated Enrollment: | 40 |
Study Start Date: | January 2007 |
Estimated Study Completion Date: | December 2008 |
Estimated Primary Completion Date: | December 2008 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
---|---|
paroxetine cr
single arm
|
Drug: Paxil CR
12 week treatment of Paxil(20-40mg)
|
Ages Eligible for Study: | 20 Years to 60 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: Eun-Ho Kang, M.D. | +82-2-3410-1384 | psychotx@naver.com |
Korea, Republic of | |
Samsung Medical Center | Recruiting |
Seoul, Korea, Republic of, 135-710 | |
Contact: Eun-Ho Kang, M.D. +82-2-3410-1384 psychotx@naver.com |
Principal Investigator: | Bum-Hee Yu, M.D., Ph.D. | Samsung Medical Center |
Responsible Party: | Department of Psychiatry, Samsung Medical Center ( Bum-Hee Yu, M.D. Ph.D. / Professor ) |
Study ID Numbers: | SMC IRB 2006-07-091 |
Study First Received: | October 6, 2008 |
Last Updated: | October 6, 2008 |
ClinicalTrials.gov Identifier: | NCT00767754 History of Changes |
Health Authority: | Korea: Food and Drug Administration |
panic disorder paroxetine PET |
Panic Disorder Anxiety Disorders Mental Disorders Paroxetine |
Panic Disorder Pathologic Processes Disease Anxiety Disorders Mental Disorders |