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Sponsors and Collaborators: |
Johns Hopkins University Eli Lilly and Company |
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Information provided by: | Johns Hopkins University |
ClinicalTrials.gov Identifier: | NCT00286949 |
Atomoxetine (Strattera) is a drug that is currently approved for treatment of attention deficit hyperactivity disorder (ADHD) in children and adults.
Atomoxetine works to enhance levels of brain chemicals that may be affected in people with executive dysfunction, (difficulties with organization, task completion, and priority setting). Thus, atomoxetine has the potential to improve executive dysfunction in people with Parkinson's disease (PD).
The goal of this study is to provide preliminary data on the effectiveness and tolerability of atomoxetine for the treatment of executive dysfunction in patients with PD.
Condition | Intervention |
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Parkinson's Disease |
Drug: Atomoxetine (Strattera) |
Study Type: | Interventional |
Study Design: | Treatment, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Safety/Efficacy Study |
Official Title: | Atomoxetine for the Treatment of Executive Dysfunction in Patients With Parkinson's Disease: A Pilot Open-Label Study |
Estimated Enrollment: | 12 |
Study Start Date: | September 2004 |
Estimated Study Completion Date: | September 2006 |
Parkinson’s disease (PD), while defined by its motor abnormalities and associated dopaminergic loss, is invariably accompanied by cognitive impairment.
Early in the disease course, the deficits are characterized by executive dysfunction with difficulties on tasks that involve information processing, attention, sorting, planning, set-shifting, and working memory and are subserved by neural connections with prefrontal brain regions. There has been little effort to identify treatments for these PD-related cognitive impairments, despite their disabling and distressing effects. Accordingly, the goal of this proposal is to conduct a small pilot study to determine the effectiveness and tolerability of atomoxetine, a selective norepinephrine reuptake inhibitor, for the treatment of executive dysfunction in patients with PD.
Atomoxetine (Strattera) is currently approved by the FDA for treatment of attention deficit hyperactivity disorder (ADHD) in children and adults.
Atomoxetine enhances dopaminergic and noradrenergic transmission in frontal regions that are also implicated in executive dysfunction and thus has the potential to improve executive dysfunction in PD as well as other neurological conditions. Results of the study will be used to develop a larger placebo-controlled trial of atomoxetine, if appropriate, as well as inform the design of other clinical trials on potential treatments for cognitive dysfunction in PD.
The overall hypothesis is that atomoxetine will be an effective and safe treatment for executive dysfunction in PD.
Ages Eligible for Study: | 21 Years to 65 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
United States, Maryland | |
Johns Hopkins Hospital | |
Baltimore, Maryland, United States, 21287 |
Principal Investigator: | Laura Marsh, MD | Johns Hopkins University |
Study ID Numbers: | WIRB#20040223, B4Z-US-X029 |
Study First Received: | February 3, 2006 |
Last Updated: | July 25, 2006 |
ClinicalTrials.gov Identifier: | NCT00286949 History of Changes |
Health Authority: | United States: Institutional Review Board |
Parkinson's disease executive dysfunction impairment motor skills cognitive |
Neurotransmitter Agents Ganglion Cysts Adrenergic Agents Movement Disorders Parkinson Disease Basal Ganglia Diseases |
Atomoxetine Central Nervous System Diseases Parkinsonian Disorders Neurodegenerative Diseases Brain Diseases |
Neurotransmitter Uptake Inhibitors Neurotransmitter Agents Adrenergic Agents Molecular Mechanisms of Pharmacological Action Adrenergic Uptake Inhibitors Physiological Effects of Drugs Basal Ganglia Diseases Nervous System Diseases |
Central Nervous System Diseases Atomoxetine Brain Diseases Neurodegenerative Diseases Pharmacologic Actions Parkinson Disease Movement Disorders Parkinsonian Disorders |