Urinary Aquaporin 2 and Expression of the NPHS2 Gene in Adults Suffering From Nephrotic Syndrome

This study is currently recruiting participants.

Verified by Holstebro Hospital, March 2009

First Received: February 3, 2006 Last Updated: March 2, 2009 History of Changes

Sponsored by:	Holstebro Hospital
Information provided by:	Holstebro Hospital
ClinicalTrials.gov Identifier:	NCT00286910

Purpose

We want to test the hypothesises that patients with nephrotic syndrome have a higher excretion of AQP2 in the urine,that they have a higher concentration of AVP,and a lower C-H2O.Everything will normalize, when the syndrome is in remission.Furthermore we want to test the hypothesis that the expression of mutations in the NPHS2-gene,that codes for podocin,will cause a lack off or a poorer response in the treatment of nephrotic syndrome

Condition	Phase
Nephrotic Syndrome	Phase IV

U.S. FDA Resources

Study Type:	Observational
Study Design:	Case Control, Retrospective
Official Title:	Urinary Aquaporin 2 and Expression of the NPHS2 Gene in Adults Suffering From Nephrotic Syndrome

Further study details as provided by Holstebro Hospital:

Estimated Enrollment:	150
Study Start Date:	May 2005

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes
Sampling Method:	Probability Sample

Study Population

adult patients with nephrotic syndrome healthy volunteers

Criteria

Inclusion Criteria:

adult patients with nephrotic syndrome in the years 1995 until now; both male and female; the kidney disease must be based upon a kidney biopsy ; age > 18 years -

Exclusion Criteria:

severe diseases in the heart, lungs or liver; diabetes mellitus; other not well-treated diseases in endocrine organs; cancer unwillingness to participate

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00286910

Contacts

Contact: Ingrid Moeller Thomsen, MD

+4599125426

aimt@ringamt.dk

Locations

Denmark
Department of Medicine, Holstebro Hospital	Recruiting
Holstebro, Denmark, 7500
Contact: Ingrid M Thomsen, MD +4599125428 aimt@ringamt.dk
Principal Investigator: Ingrid M Thomsen, MD

Sponsors and Collaborators

Holstebro Hospital

Investigators

Study Chair:

Erling B Pedersen, professor

Holstebro Hospital, Denmark

More Information

No publications provided

Responsible Party:	Erling Bjerregaard Pedersen ( Holstebro Hospital )
Study ID Numbers:	MED.RES.HOS.2005.05/ IMT
Study First Received:	February 3, 2006
Last Updated:	March 2, 2009
ClinicalTrials.gov Identifier:	NCT00286910 History of Changes
Health Authority:	Denmark: Ethics Committee

Keywords provided by Holstebro Hospital:

AQP-2
NPHS2-gene

Study placed in the following topic categories:

Nephrosis
Urologic Diseases
Kidney Diseases
Nephrotic Syndrome

Additional relevant MeSH terms:

Nephrosis
Pathologic Processes
Disease
Urologic Diseases

Syndrome
Kidney Diseases
Nephrotic Syndrome

ClinicalTrials.gov processed this record on May 07, 2009