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Sponsored by: |
Tel-Aviv Sourasky Medical Center |
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Information provided by: | Tel-Aviv Sourasky Medical Center |
ClinicalTrials.gov Identifier: | NCT00391495 |
The aim of this study is to investigate the inflammatory response in children with this disorder.
Condition | Intervention |
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Attention-Deficit/Hyperactivity Disorder |
Procedure: Blood drawing |
Study Type: | Observational |
Study Design: | Cross-Sectional, Case Control, Prospective Study |
Official Title: | Inflammation in Children With Attention-Deficit/Hyperactivity Disorder |
Estimated Enrollment: | 45 |
Study Start Date: | September 2007 |
Estimated Study Completion Date: | December 2007 |
Attention deficit-hyperactivity disorder (ADHD) is a prevalent childhood neuropsychiatric disorder, characterized by age-inappropriate and impairing levels of inattention, hyperactivity and impulsiveness. Approximately 5-10% of school-age children are affected by ADHD, and in many cases, symptoms persist into adolescence and adulthood.
Cytokines are key mediators of immune function and can be either pro-inflammatory or anti-inflammatory. Recently few studies have suggested involvement of cytokine pathways in subjects with ADHD.
Polymorphism of IL-1 receptors antagonists' alleles have been suggested in families and subjects suffering from ADHD. Moreover, a new variant of inflammatory bowel disease, another immunological based disease, was recently suggested in children with ADHD and other developmental disorders. There are no other published reports on cytokine production in children who suffer from ADHD.
Ages Eligible for Study: | 9 Years to 13 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: Nachum Vaisman, Prof. (MD) | 972-3-6974807 | vaisman@tasmc.health.gov.il |
Israel | |
The Unit of Clinical Nutrition | |
Tel Aviv, Israel |
Principal Investigator: | Nachum Vaisman, Prof. (MD) | Tel-Aviv Sourasky Medical Center |
Principal Investigator: | Nachum Vaisman, Prof. (MD) | Tel-Aviv Sourasky Medical Center |
Study ID Numbers: | TASMC-06-NV-246-CTIL |
Study First Received: | October 22, 2006 |
Last Updated: | June 18, 2007 |
ClinicalTrials.gov Identifier: | NCT00391495 History of Changes |
Health Authority: | Israel: Ethics Commission |
ADHD Cytokines CR-P |
Signs and Symptoms Attention Deficit Disorder with Hyperactivity Mental Disorders Mental Disorders Diagnosed in Childhood Neurologic Manifestations |
Attention Deficit and Disruptive Behavior Disorders Hyperkinesis Dyskinesias Inflammation |
Signs and Symptoms Pathologic Processes Disease Attention Deficit Disorder with Hyperactivity Mental Disorders Nervous System Diseases |
Mental Disorders Diagnosed in Childhood Neurologic Manifestations Attention Deficit and Disruptive Behavior Disorders Hyperkinesis Dyskinesias Inflammation |