Scientific Evaluation of Peer Education and STD Treatment to Reduce the Spread of HIV in Zimbabwe

This study has been completed.

First Received: October 20, 2006 Last Updated: January 9, 2007 History of Changes

Sponsors and Collaborators:	Imperial College London Biomedical Research and Training Institute, Harare
Information provided by:	Imperial College London
ClinicalTrials.gov Identifier:	NCT00390949

Purpose

The purpose of this study is to determine whether community-based peer education and condom distribution combined with improved treatment of sexually transmitted infections are effective in reducing the spread of HIV infection in a sub-Saharan African population

Condition	Intervention
HIV Infections	Behavioral: Peer education among commercial sex workers and clients Behavioral: Condom distribution and promotion Procedure: Syndromic treatment of sexually transmitted infections Procedure: Systemic counselling for STI patients

MedlinePlus related topics: AIDS Sexually Transmitted Diseases

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Prevention, Randomized, Open Label, Active Control, Parallel Assignment, Efficacy Study
Official Title:	Impact and Process Evaluation of Integrated Community and Clinic-Based HIV-1 Control: a Cluster-Randomised Trial in Eastern Zimbabwe

Further study details as provided by Imperial College London:

Primary Outcome Measures:

HIV incidence at the community level

Secondary Outcome Measures:

Self-reported genital ulcers
Self-reported urethral or genital discharge
Sexually transmitted infection treatment effectiveness (self-reported cessation of symptoms)
Sexual behaviour change (sexual debut, sexual partner change, non-regular partners, unprotected sex with regular and casual partners)
Health-seeking behaviour change
HIV/AIDS knowledge

Study Start Date:	July 1998
Estimated Study Completion Date:	February 2003

Show Detailed Description

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria: - All members of study communities

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00390949

Locations

Zimbabwe
Biomedical Research and Training Institute
Harare, Zimbabwe

Sponsors and Collaborators

Imperial College London

Biomedical Research and Training Institute, Harare

Investigators

Principal Investigator:	Simon Gregson, DPhil	Imperial College London
Principal Investigator:	Stephen Chandiwana, PhD	Biomedical Research and Training Institute

More Information

Additional Information:

Manicaland HIV/STD Prevention Project website This link exits the ClinicalTrials.gov site

Department of Infectious Disease Epidemiology, Imperial College London This link exits the ClinicalTrials.gov site

Biomedical Research and Training Institute, Harare This link exits the ClinicalTrials.gov site

Publications:

Gregson S, Garnett GP, Nyamukapa CA, Hallett TB, Lewis JJ, Mason PR, Chandiwana SK, Anderson RM. HIV decline associated with behavior change in eastern Zimbabwe. Science. 2006 Feb 3;311(5761):664-6.

Study ID Numbers:	PC3239_DFID
Study First Received:	October 20, 2006
Last Updated:	January 9, 2007
ClinicalTrials.gov Identifier:	NCT00390949 History of Changes
Health Authority:	United Kingdom: Research Ethics Committee

Keywords provided by Imperial College London:

HIV prevention
Zimbabwe
Core groups
Peer education

Syndromic management
Commercial sex workers
Condom distribution
HIV Seronegativity

Study placed in the following topic categories:

Virus Diseases
Sexually Transmitted Diseases, Viral
HIV Infections
Sexually Transmitted Diseases

Acquired Immunodeficiency Syndrome
Retroviridae Infections
Immunologic Deficiency Syndromes

Additional relevant MeSH terms:

Virus Diseases
Sexually Transmitted Diseases, Viral
RNA Virus Infections
Slow Virus Diseases
Immune System Diseases
HIV Infections

Sexually Transmitted Diseases
Acquired Immunodeficiency Syndrome
Lentivirus Infections
Infection
Retroviridae Infections
Immunologic Deficiency Syndromes

ClinicalTrials.gov processed this record on May 07, 2009