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Sponsored by: |
National Taiwan University Hospital |
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Information provided by: | National Taiwan University Hospital |
ClinicalTrials.gov Identifier: | NCT00172224 |
The etiology and pathogenesis of osteoporosis has been extensively discussed. The relationship between bone blood circulation and the formation of bony trabeculae has been less understood. There is plenty of indirect evidence highly suggestive of the correlation between these two factors, such as: the number of blood vessels in the per unit area of the bone marrow was decreased in the osteoporotic bone, indicating the possible role of a microvascular defect in the pathogenesis of osteoporosis. Furthermore, the bone mineral density in severe arteriosclerotic patients was lower than in the less affected subjects. In a large scale epidemiologic study, diminished bone mineral density was strongly associated with increased deaths from stroke. Osteopenia was also associated with an increased risk of stroke. These reports highly suggest the effect of ischemia on bone metabolism and make the investigators more interested in further investigation.
A dynamic contrast-enhanced magnetic resonance (MR) study was used recently in evaluating the blood perfusion of bone tumors. This method also has a strong correlation with the microsphere blood flow measurements. The investigator (T.F. Shih) used the dynamic MR in her recent two researches:
The alterations of bone marrow perfusion are synchronous with the changes of bone mineral density. Thus, based on the investigators' previous research work, they propose to further explore the relationship between bone marrow perfusion and bone mineral density in different age groups.
Study Type: | Observational |
Study Design: | Natural History, Cross-Sectional, Defined Population, Prospective Study |
Official Title: | Dynamic MR Study in Evaluating the Vertebral Bone Marrow Perfusion and Its Related Research |
Estimated Enrollment: | 100 |
Study Start Date: | August 2002 |
The etiology and pathogenesis of osteoporosis has been extensively discussed. The relationship between bone blood circulation and the formation of bony trabeculae has been less understood. There is plenty of indirect evidence highly suggestive of the correlation between these two factors, such as: the number of blood vessels in the per unit area of the bone marrow was decreased in the osteoporotic bone, indicating the possible role of a microvascular defect in the pathogenesis of osteoporosis. Furthermore, the bone mineral density in severe arteriosclerotic patients was lower than in the less affected subjects. In a large scale epidemiologic study, diminished bone mineral density was strongly associated with increased deaths from stroke. Osteopenia was also associated with an increased risk of stroke. These reports highly suggest the effect of ischemia on bone metabolism and make the investigators more interested in further investigation.
A dynamic contrast-enhanced magnetic resonance (MR) study was used recently in evaluating the blood perfusion of bone tumors. This method also has a strong correlation with the microsphere blood flow measurements. The investigator (T.F. Shih) used the dynamic MR in her recent two researches:
The alterations of bone marrow perfusion are synchronous with the changes of bone mineral density. Thus, based on the investigators' previous research work, they propose to further explore the relationship between bone marrow perfusion and bone mineral density in different age groups.
Ages Eligible for Study: | 20 Years to 80 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: Tiffany Ting-Fang Shih, M.D. | 886-2-23123456 ext 6993 | ttfshih@ha.mc.ntu.edu.tw |
Taiwan | |
Tiffany Ting-Fang Shih | Recruiting |
Taipei, Taiwan | |
Contact: Tiffany Ting-Fang Shih, MD 886-2-23123456 ext 6993 ttfshih@ha.mc.ntu.edu.tw | |
Contact: Tiffany Ting-Fang Shih, MD 886-2-23123456 ext 6993 ttfshih@ha.mc.ntu.edu.tw | |
Principal Investigator: Tiffany Ting-Fang Shih, MD |
Principal Investigator: | Tiffany Ting-Fang Shih, M.D. | Department of Medical Image, National Taiwan University Hospital |
Study ID Numbers: | 32244, NSC 91-2314-B-002-395, NSC 92-2314-B-002-172 |
Study First Received: | September 12, 2005 |
Last Updated: | February 28, 2006 |
ClinicalTrials.gov Identifier: | NCT00172224 History of Changes |
Health Authority: | Taiwan: Department of Health |
osteoporosis compression fracture bone marrow perfusion MR spectroscopy hormone therapy |
Fractures, Compression Musculoskeletal Diseases Fractures, Bone Wounds and Injuries Disorders of Environmental Origin |
Osteoporosis Bone Diseases, Metabolic Hormones Bone Diseases |
Fractures, Compression Musculoskeletal Diseases Fractures, Bone Wounds and Injuries |
Disorders of Environmental Origin Osteoporosis Bone Diseases, Metabolic Bone Diseases |