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Sponsors and Collaborators: |
Emory University National Institutes of Health (NIH) |
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Information provided by: | Emory University |
ClinicalTrials.gov Identifier: | NCT00228644 |
Availability of sulfur amino acids (SAA) is critical for glutathione/glutathione disulfide (GSH/GSSG) and cysteine/cystine (CYS/CYSS) redox in vivo and for many other physiologic functions including protein synthesis, nitrogen balance, digestion, osmotic regulation, detoxification, hormonal regulation, biologic methylations, and cell growth regulation. GSH conjugation and sulfate conjugation represent quantitatively important pathways for chemical detoxification, which imposes substantial burden upon SAA supply. The primary hypothesis is that SAA deficient diet and acetaminophen (APAP) administration will perturb Cys metabolism and GSH redox homeostasis in human plasma and urinary output of SAA metabolites. Because both of these variations affect SAA homeostasis, it is believed that the combination of these treatments will produce an interactive effect in which 2-day SAA deficiency will alter APAP metabolism, APAP will affect SAA homeostasis, and the treatments together will alter the global metabolic profile, as measured by 1H-NMR spectroscopy.
Condition |
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Healthy |
Study Type: | Observational |
Study Design: | Cohort, Prospective |
Official Title: | Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione and Cysteine. |
Estimated Enrollment: | 15 |
Study Start Date: | July 2005 |
Study Completion Date: | January 2009 |
Ages Eligible for Study: | 18 Months to 40 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
healthy volunteers
Inclusion Criteria:
healthy
Exclusion Criteria:
smokers greater or less than 10% of ideal body weight illness
Responsible Party: | Emory University ( Dean Jones, PhD Professor ) |
Study ID Numbers: | 501-2004 |
Study First Received: | September 27, 2005 |
Last Updated: | January 29, 2009 |
ClinicalTrials.gov Identifier: | NCT00228644 History of Changes |
Health Authority: | United States: Institutional Review Board |
oxidative stress amino acids acetaminophen dietary requirements |
Analgesics, Non-Narcotic Stress Peripheral Nervous System Agents |
Analgesics Healthy Acetaminophen |
Sensory System Agents Analgesics, Non-Narcotic Therapeutic Uses Physiological Effects of Drugs Peripheral Nervous System Agents |
Analgesics Central Nervous System Agents Pharmacologic Actions Acetaminophen |