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Sponsored by: |
Kyoto University |
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Information provided by: | Kyoto University |
ClinicalTrials.gov Identifier: | NCT00881036 |
Individuals with resolved hepatitis B, characterized as hepatitis B surface antigen (HBsAg)-negative and hepatitis B core antibody-positive, have latent hepatitis B virus (HBV) infection in their liver tissue. Cytotoxic chemotherapy and hematopoietic stem cell transplantation sometimes trigger the reactivation of latently infected HBV, resulting in de novo hepatitis B. Although de novo hepatitis B could cause acute liver failure or chronic hepatitis, an effective management strategy for de novo hepatitis B has not been well established. Risk factors and effective management for de novo hepatitis B will be clarified.
Condition |
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Hepatitis B |
Study Type: | Observational |
Study Design: | Cohort, Prospective |
Official Title: | Activation of HBV Under Immunosuppression in HBsAg-Negative But Anti-HBc-Positive Patients With Hematological Malignancies |
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Probability Sample |
HBsAg-negative but anti-HBc-positive patients with hematological malignancies treated at Kyoto University Hospital
Inclusion Criteria:
Exclusion Criteria:
Japan | |
Kyoto Univesity | Recruiting |
Kyoto, Japan, 606-8507 | |
Contact: Yoshihide Ueda, M.D. and Ph.D. 81-75-751-3111 yueda@kuhp.kyoto-u.ac.jp | |
Principal Investigator: Yoshihide Ueda, M.D. and Ph.D. |
Responsible Party: | Kyoto University Hospital ( Yoshihide Ueda/Assistant Professor ) |
Study ID Numbers: | HBV from anti-HBc positive |
Study First Received: | April 13, 2009 |
Last Updated: | April 13, 2009 |
ClinicalTrials.gov Identifier: | NCT00881036 History of Changes |
Health Authority: | Japan: Ministry of Education, Culture, Sports, Science and Technology |
Hepatitis B |
Virus Diseases Hepatitis Antibodies Liver Diseases Digestive System Diseases |
Hepatitis B Hepatitis, Viral, Human DNA Virus Infections Immunoglobulins |
Virus Diseases Hepatitis Liver Diseases Digestive System Diseases |
Hepatitis B Hepatitis, Viral, Human DNA Virus Infections Hepadnaviridae Infections |