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| Sponsors and Collaborators: |
Department of Veterans Affairs University of Alabama at Birmingham |
|---|---|
| Information provided by: | Department of Veterans Affairs |
| ClinicalTrials.gov Identifier: | NCT00880555 |
Purpose
Alzheimer's disease often manifests as a memory disorder before dementia develops. Dementia is considered to be present when a person can no longer handle complex activities of daily living, such as managing finances. This study will investigate the relationship between changes in the ability to manage finances and brain perfusion, which will be measured using continuous arterial spin-labeling (an experimental MRI). Subjects will also undergo neuropsychological tests focusing on several types of memory and thought process, with special emphasis on semantic memory. An important question to be addressed is whether changes in function are better predicted by the neuropsychological tests or by the brain scan.
| Condition |
|---|
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Alzheimer Disease Dementia |
| Study Type: | Observational |
| Study Design: | Prospective |
| Official Title: | Semantic Memory, Financial Capacity and Brain Perfusion in MCI |
| Estimated Enrollment: | 160 |
| Study Start Date: | April 2009 |
| Estimated Study Completion Date: | December 2014 |
| Estimated Primary Completion Date: | December 2014 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
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1
Patients with non-dementia memory disorder (mild cognitive impairment)
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2
Elderly controls without memory impairment
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Eligibility| Ages Eligible for Study: | 50 Years to 89 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Probability Sample |
160 subjects are anticipated, with the expectation that initial cognitive evaluations will exclude about 60 subjects. We intend to maintain and follow 100 subjects, 60 with non-dementia memory impairment (meeting criteria for amnestic MCI) and 40 with no cognitive impairment
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Contact: David G Clark, MD | (205) 996-6050 | dgclark@uab.edu |
| Contact: Kathryn L Burgio, PhD MA BA | (205) 933-8101 ext 7307 | kathryn.burgio@va.gov |
| United States, Alabama | |
| VA Medical Center, Birmingham | |
| Birmingham, Alabama, United States, 35233 | |
| Principal Investigator: | David G Clark, MD | VA Medical Center, Birmingham |
More Information
| Responsible Party: | Department of Veterans Affairs ( Clark, David - Principal Investigator ) |
| Study ID Numbers: | E6553W |
| Study First Received: | April 10, 2009 |
| Last Updated: | April 10, 2009 |
| ClinicalTrials.gov Identifier: | NCT00880555 History of Changes |
| Health Authority: | United States: Federal Government |
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Magnetic Resonance Imaging Alzheimer disease Mild cognitive impairment Continuous arterial spin labeling Semantic memory |
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Delirium, Dementia, Amnestic, Cognitive Disorders Mental Disorders Alzheimer Disease Central Nervous System Diseases Neurodegenerative Diseases |
Brain Diseases Dementia Cognition Disorders Delirium |
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Delirium, Dementia, Amnestic, Cognitive Disorders Mental Disorders Nervous System Diseases Alzheimer Disease Central Nervous System Diseases |
Neurodegenerative Diseases Tauopathies Brain Diseases Dementia |
