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Safety and Efficacy of Gabapentin in Postherpetic Neuralgia
This study is currently recruiting participants.
Verified by Depomed, December 2008
First Received: February 21, 2008   Last Updated: December 22, 2008   History of Changes
Sponsored by: Depomed
Information provided by: Depomed
ClinicalTrials.gov Identifier: NCT00636636
  Purpose

Gabapentin and pregabalin are treatments for some types of neuropathic pain, including postherpetic neuralgia (PHN). However, these treatments usually need to be taken 3 times a day for effective pain control. The purpose of this study is to determine whether a new gabapentin tablet, which only needs to be taken once a day, is safe and effective for the treatment of postherpetic neuralgia.


Condition Intervention Phase
Neuralgia,Postherpetic
Drug: Gabapentin Extended Release tablets
Phase III

MedlinePlus related topics: Shingles
Drug Information available for: Gabapentin
U.S. FDA Resources
Study Type: Interventional
Study Design: Treatment, Randomized, Double Blind (Subject, Investigator), Placebo Control, Parallel Assignment, Safety/Efficacy Study
Official Title: A Phase 3 Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Efficacy of Gabapentin Extended Release (G-ER) Tablets in the Treatment of Patients With Postherpetic Neuralgia

Further study details as provided by Depomed:

Primary Outcome Measures:
  • The primary study objective is to assess the relative efficacy of G-ER versus placebo in reducing the average daily pain score from the baseline week to the final week of the efficacy treatment period (Treatment Week 10) in patients with PHN [ Time Frame: 10 weeks ] [ Designated as safety issue: No ]
  • Daily pain scores will be measured using an electronic diary. [ Time Frame: 10 weeks ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Secondary objectives include assessment of changes from baseline in average daily sleep interference scores [ Time Frame: 10 weeks ] [ Designated as safety issue: No ]

Estimated Enrollment: 450
Study Start Date: February 2008
Estimated Study Completion Date: September 2009
Estimated Primary Completion Date: June 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
2: Experimental Drug: Gabapentin Extended Release tablets
Once-Daily

Detailed Description:

The primary study objective is to assess the relative efficacy of G-ER dosed once daily (1800 mg following the evening meal), versus placebo in reducing the mean daily pain score from the baseline week to the end of the efficacy treatment period (Treatment Week 10) in patients with PHN.

Secondary efficacy measures will include changes from baseline in mean weekly sleep interference scores, Short-Form McGill Pain Questionnaire (SF-MPQ), the Neuropathic Pain Scale (NPS), Brief Pain Inventory (BPI), Patient Global Impression of Change (PGIC), and Investigator-Rated Clinical Global Impression of Change (CGIC).

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  1. Men or women 18 years or older who have experienced pain for at least 6 months, but not more than 5 years after the healing of a herpes zoster skin rash(typically about 4 months after the rash first appears).
  2. Patient has a pain intensity score of at least 4 on the 11-point Numerical Rating Scale (NRS). Patients should never be informed of the pain intensity criterion prior to screening or randomization.
  3. Patients of child-bearing potential must have a negative serum pregnancy test at screening and a negative follow-up urine pregnancy test at randomization.
  4. Patient has a mean baseline week pain intensity score of at least 4 on the 11-point NRS scale at the end of a 1-week baseline period and has completed at least 4 days of daily pain diary entries during the baseline week.
  5. Patients must have a minimum washout period of greater than 5 times the half-life of the drug of several medications.
  6. Patients currently treated with gabapentin pr pregabalin at screening may be eligible for the study, but must have a tapering period wherein the dose of gabapentin or pregabalin is reduced gradually over a period of 5 days followed by a two day washout prior to the Baseline Week.

Exclusion Criteria:

  1. Patients who have previously not responded to treatment for PHN with gabapentin or pregabalin.
  2. Patients who previously experienced dose-limiting adverse effects that prevented titration of gabapentin to an effective dose.
  3. Patient is a nursing mother.
  4. Patient has hypersensitivity to gabapentin.
  5. Patient has had neurolytic or neurosurgical treatment for PHN.
  6. Patient has severe pain from causes other than PHN.
  7. Patient has used injected anesthetics or steroids within 30 days of baseline.
  8. Patient has skin conditions in the area affected by the neuropathy that could alter sensation.
  9. Patient is in an immunocompromised state.
  10. Patient has an estimated creatinine clearance less than 50 ml/min.
  11. Patient has had malignancy within past 2 years other than basal cell carcinoma.
  12. Patient has had gastric reduction surgery.
  13. Patient has severe chronic diarrhea, chronic constipation [unless attributed to drugs that will be washed out], uncontrolled irritable bowel syndrome (IBS) or unexplained weight loss.
  14. Patient has any abnormal chemistry or hematology results that are deemed by the investigator to be clinically significant.
  15. Patient has a history of substance abuse within the past year.
  16. Patient has a history of seizure (except for infantile febrile seizure) or is at risk of seizure due to head trauma.
  17. Patient has a history of chronic hepatitis B or C, hepatitis within the past 3 months, or HIV infection.
  18. Patient has any other clinically significant medical or psychological condition that, in the opinion of the Investigator would jeopardize the safety of the patient or affect the validity of the study results.
  19. Continuing use of any concomitant medication excluded by Inclusion Criterion 5.
  20. Patient has participated in a clinical trial of an investigational drug or device within 30 days of the screening visit.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00636636

Contacts
Contact: Jackie Givens 512-292-9474 Jackie.Givens@austin.ppdi.com

  Show 37 Study Locations
Sponsors and Collaborators
Depomed
  More Information

No publications provided

Responsible Party: Depomed, Inc ( Michelle Heritier )
Study ID Numbers: 81-0062
Study First Received: February 21, 2008
Last Updated: December 22, 2008
ClinicalTrials.gov Identifier: NCT00636636     History of Changes
Health Authority: United States: Institutional Review Board

Keywords provided by Depomed:
Postherpetic Neuralgia (PHN), shingles

Study placed in the following topic categories:
Herpes Zoster
Neuralgia, Postherpetic
Excitatory Amino Acids
Neurotransmitter Agents
Tranquilizing Agents
Neuralgia
Gabapentin
Psychotropic Drugs
Central Nervous System Depressants
Calcium Channel Blockers
Pain
Cardiovascular Agents
Antimanic Agents
Signs and Symptoms
Calcium, Dietary
Neuromuscular Diseases
Peripheral Nervous System Diseases
Neurologic Manifestations
Anti-Anxiety Agents
Analgesics
Peripheral Nervous System Agents
Anticonvulsants

Additional relevant MeSH terms:
Neuralgia, Postherpetic
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Gabapentin
Anti-Dyskinesia Agents
Physiological Effects of Drugs
Psychotropic Drugs
Antiparkinson Agents
Calcium Channel Blockers
Excitatory Amino Acid Agents
Pain
Membrane Transport Modulators
Signs and Symptoms
Neuromuscular Diseases
Sensory System Agents
Therapeutic Uses
Analgesics
Excitatory Amino Acid Antagonists
Tranquilizing Agents
Neuralgia
Nervous System Diseases
Central Nervous System Depressants
Cardiovascular Agents
Antimanic Agents
Pharmacologic Actions
Peripheral Nervous System Diseases
Neurologic Manifestations
Anti-Anxiety Agents
Peripheral Nervous System Agents
Central Nervous System Agents

ClinicalTrials.gov processed this record on May 07, 2009