Protective Effect of Coronary Collaterals on Infarct Size in Patients With Acute Myocardial Infarction - Full Text View

Sponsors and Collaborators:	University Hospital Inselspital, Berne Swiss National Science Foundation
Information provided by:	University Hospital Inselspital, Berne
ClinicalTrials.gov Identifier:	NCT00412672

Purpose

The hypothesis of the current proposal is that collateral flow is an important determinant of myocardial protection during an ischemic event. Increased collateral flow for any given area at risk will decrease the myocardial damage caused by the occlusion of the infarct related epicardial artery.

It is further hypothesized that myocardial salvage provided by collateral flow will decrease infarct size and this in turn will decrease LV dilatation post-myocardial infarction.

Condition
Myocardial Infarction

MedlinePlus related topics: Heart Attack

U.S. FDA Resources

Study Type:	Observational
Study Design:	Screening, Cross-Sectional, Defined Population, Prospective Study
Official Title:	Protective Effect of Coronary Collaterals on Infarct Size in Patients With Acute Myocardial Infarction

Further study details as provided by University Hospital Inselspital, Berne:

Estimated Enrollment:	105
Study Start Date:	January 2007
Estimated Study Completion Date:	January 2008

Detailed Description:

The hypothesis of the current proposal is that collateral flow is an important determinant of myocardial protection during an ischemic event. Increased collateral flow for any given area at risk will decrease the myocardial damage caused by the occlusion of the infarct related epicardial artery.

It is further hypothesized that myocardial salvage provided by collateral flow will decrease infarct size and this in turn will decrease LV dilatation post-myocardial infarction. The two primary endpoints are infarct size as assessed by increase of biochemical cardiac markers and coronary collateral perfusion index (CPI) as obtained by transthoracic MCE. Extent of LV remodelling, i.e., LV dilatation as assessed by serial assessment of LV dimension by LV angiogram and/or echocardiography, respectively.

Eligibility

Ages Eligible for Study:	18 Years to 80 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Patients with acute myocardial infarction with electrocardiographic criterion and/or typical history of angina pectoris and planned revascularisation according to the acute myocardial infarction disease management guidelines of the University Hospital Bern. Including both, patients undergoing primary PCI and patients referred for rescue PCI after failed thrombolytic therapy
Patients > 18 years old of either sex
Patients who have given informed consent to the study

Exclusion Criteria:

Patients unable to give informed consent e.g. because of mechanical ventilation
Patients with cardiogenic shock
Patients with myocardial infarction secondary to occlusion of a recently revascularized vessel (subacute stent thrombosis)
Patients with severe arrhythmias
Patients whose door-to-balloon time exceeds 120 minutes
Pregnancy

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00412672

Contacts

Contact: Tobias Rutz, MD

+41 6321 12 77

tobias.rutz@insel.ch

Locations

Switzerland
University Hospital Inselspital
Bern, Switzerland, 3010

Sponsors and Collaborators

University Hospital Inselspital, Berne

Swiss National Science Foundation

Investigators

Principal Investigator:

Christian Seiler, Prof.

University Hospital Bern, Switzerland

More Information

No publications provided

Study ID Numbers:	37/01
Study First Received:	December 15, 2006
Last Updated:	December 15, 2006
ClinicalTrials.gov Identifier:	NCT00412672 History of Changes
Health Authority:	Switzerland: Swissmedic

Keywords provided by University Hospital Inselspital, Berne:

Myocardial infarction
contrast echocardiography
collateral circulation

Study placed in the following topic categories:

Necrosis
Heart Diseases
Myocardial Ischemia
Vascular Diseases

Ischemia
Infarction
Myocardial Infarction

Additional relevant MeSH terms:

Necrosis
Heart Diseases
Pathologic Processes
Myocardial Ischemia
Vascular Diseases

Cardiovascular Diseases
Ischemia
Infarction
Myocardial Infarction

ClinicalTrials.gov processed this record on May 07, 2009