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Sponsored by: |
Kwong Wah Hospital |
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Information provided by: | Kwong Wah Hospital |
ClinicalTrials.gov Identifier: | NCT00279123 |
Endoscopic treatment of bleeding peptic ulcers is effective to prevent rebleeding. Adjuvant medical treatment to increase gastric pH may further decrease rebleeding. Recent studies on potent acid suppression by proton pump inhibitors (PPI) demonstrated the efficacy in preventing rebleeding. Lau demonstrated that high dose intravenous infusion of omeprazole decreased rebleeding in peptic ulcers with stigmata of recent hemorrhage.
There is little data regarding the effect of pantoprazole on bleeding peptic ulcers. Furthermore, the optimal dose of PPI is unknown. Few studies have included measurement of gastric pH in addition to clinical outcome.
This study compares the effect of two doses of intravenous pantoprazole with no acid suppression in bleeding peptic ulcers after endoscopic therapy. In addition to the usual clinical endpoints, gastric pH is monitored to study the relation of pH elevation and the clinical outcome.
Condition | Intervention | Phase |
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Peptic Ulcer Hemorrhage |
Drug: pantoprazole infusion Drug: pantoprazole bolus Drug: no treatment |
Phase IV |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Open Label, Placebo Control, Parallel Assignment, Efficacy Study |
Genders Eligible for Study: | Both |
Inclusion Criteria:
Exclusion Criteria:
Study ID Numbers: | PPI Trial |
Study First Received: | January 17, 2006 |
Last Updated: | January 17, 2006 |
ClinicalTrials.gov Identifier: | NCT00279123 History of Changes |
Health Authority: | Hong Kong: Hospital Authority |
Stomach Diseases Digestive System Diseases Gastrointestinal Diseases Pantoprazole Ulcer Peptic Ulcer Hemorrhage |
Gastrointestinal Hemorrhage Intestinal Diseases Hemorrhage Duodenal Diseases Recurrence Peptic Ulcer |
Gastrointestinal Diseases Ulcer Pantoprazole Gastrointestinal Agents Gastrointestinal Hemorrhage Hemorrhage Intestinal Diseases Pharmacologic Actions |
Pathologic Processes Digestive System Diseases Stomach Diseases Therapeutic Uses Peptic Ulcer Hemorrhage Anti-Ulcer Agents Peptic Ulcer Duodenal Diseases |