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Sponsors and Collaborators: |
Fundacion Clinic per a la Recerca Biomédica Carlos III Health Institute |
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Information provided by: | Fundacion Clinic per a la Recerca Biomédica |
ClinicalTrials.gov Identifier: | NCT00860366 |
The purpose of this study is to determine whether the combined treatment with Uric Acid and rtPA is superior to rtPA alone in terms of clinical efficacy in acute ischemic stroke patients treated within the first 4.5 hours of symptoms onset.
Condition | Intervention | Phase |
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Acute Ischemic Stroke |
Drug: Uric Acid Other: Vehicle |
Phase II Phase III |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Placebo Control, Parallel Assignment, Efficacy Study |
Official Title: | Randomized, Double Blind Study Assessing the Clinical Efficacy of Combined Treatment With Uric Acid and rtPA Administered Intravenously in Acute Ischemic Stroke Patients Within the First 4.5 Hours of Symptoms Onset |
Estimated Enrollment: | 420 |
Study Start Date: | September 2009 |
Estimated Study Completion Date: | September 2012 |
Estimated Primary Completion Date: | September 2012 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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Uric Acid: Experimental
Single intravenous infusion of 1 gram of Uric Acid dissolved in vehicle (500 ml of 0'1% Lithium Carbonate and 5% Mannitol).
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Drug: Uric Acid
1 gram dissolved in a vehicle containing 500 ml of 0'1% Lithium Carbonate and 5% Mannitol, IV (in the vein), single dose.
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Vehicle: Placebo Comparator
Single intravenous infusion of a 500 ml vehicle containing 0'1% Lithium Carbonate and 5% Mannitol.
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Other: Vehicle
Single intravenous infusion of a 500 ml vehicle containing 0'1% Lithium Carbonate and 5% Mannitol.
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Oxidative stress is a major contributor to brain damage in patients with ischemic stroke. Uric acid (UA) is an endogenous product derived from the metabolism of purins which in man is responsable of the 60% of the total antioxidant capacity of the organism. Recent experimental evidences gathered by our and other research groups have shown that the exogenous administration of UA is neuroprotective both in cortical and subcortical brain areas as the result of its antioxidant properties. In these studies, animals treated with UA disclosed smaller brain infarction after transient focal ischemia, both using the intraluminal model or after the injection of autologous clots. Moreover, our group first described greater neuroprotection in animals pretreated with rtPA (alteplase). Likewise, we have recently shown that the administration of UA was free of serious adverse effects in stroke patients receiving rtPA within 3 hours of stroke onset. Yet, preliminary data suggested that this intervention might translate into clinical benefits at 3 months follow-up. Based on these data, we aim to conduct a phase 3, randomized, double-blind, controlled trial assessing the clinical efficacy of UA administration in acute ischemic stroke patients. Currently, rtPA is the only approved therapy for stroke patients within the first hours of clinical onset, and oxidative stress is thought particularly relevant following ischemia/reperfusion. Based on this ground, we aim to conduct this phase 3 clinical trial in ischemic stroke patients which are currently treated with rtPA within the 4'5 hour window.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion criteria:
Exclusion criteria:
Contact: Ángel Chamorro, MD, PhD. | +34 932275400 ext 2424 | mvargas@clinic.ub.es |
Spain | |
Hospital General Universitario de Albacete | |
Albacete, Spain, 02006 | |
Hospital Clínic de Barcelona | |
Barcelona, Spain, 08036 | |
Hospital de la Santa Creu y Sant Pau | |
Barcelona, Spain, 08025 | |
Hospital Dr Josep Trueta | |
Girona, Spain, 17007 | |
Spain, Barcelona | |
Corporació Sanitària del Parc Taulí | |
Sabadell, Barcelona, Spain, 08208 | |
Spain, Navarra | |
Hospital de Navarra | |
Pamplona, Navarra, Spain, 31008 |
Study Director: | Angel Chamorro, MD, PhD. | Comprehensive Stroke Center, Hospital Clínic Barcelona, Spain. |
Responsible Party: | Comprehensive Stroke Center, Hospital Clínic Barcelona, Spain ( Ángel Chamorro Sánchez; MD, PhD ) |
Study ID Numbers: | URICOICTUS-1-2007, EudraCT 2007-002687-95, FIS EC07-90276 |
Study First Received: | March 11, 2009 |
Last Updated: | March 11, 2009 |
ClinicalTrials.gov Identifier: | NCT00860366 History of Changes |
Health Authority: | Spain: Spanish Agency of Medicines |
Acute ischemic stroke thrombolysis alteplase |
uric acid neuroprotection oxidative stress |
Antioxidants Cerebral Infarction Stroke Vascular Diseases Tissue Plasminogen Activator Stress Central Nervous System Diseases Lithium Carbonate Ischemia |
Brain Diseases Cerebrovascular Disorders Uric Acid Mannitol Brain Ischemia Brain Infarction Infarction Lithium |
Antioxidants Molecular Mechanisms of Pharmacological Action Cerebral Infarction Physiological Effects of Drugs Stroke Nervous System Diseases Vascular Diseases Central Nervous System Diseases Ischemia |
Brain Diseases Protective Agents Cerebrovascular Disorders Pharmacologic Actions Uric Acid Pathologic Processes Brain Ischemia Cardiovascular Diseases Brain Infarction |