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Sponsored by: |
University of California, San Francisco |
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Information provided by: | University of California, San Francisco |
ClinicalTrials.gov Identifier: | NCT00514722 |
This is a pilot study designed to evaluate the safety and feasibility of performing umbilical cord blood transplants in adults with high-risk hematopoietic malignancies. A novel myeloablative preparative regimen will be used. One, up to a maximum of three cord blood units will be administered to facilitate engraftment.
Condition |
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Acute Myeloid Leukemia Myelodysplasia Acute Lymphoblastic Leukemia Chronic Myelogenous Leukemia Multiple Myeloma Lymphoma, Large-Cell, Diffuse Lymphoma, Mantle-Cell Lymphoma, T-Cell, Peripheral T-NK Cell Lymphoma Hodgkin Disease |
Study Type: | Observational |
Study Design: | Prospective |
Official Title: | Pilot Study of Umbilical Cord Blood Transplantation in Adult Patient With Advanced Hematopoietic Malignancies |
Estimated Enrollment: | 4 |
Study Start Date: | October 2002 |
This study intends to demonstrate an engraftment rate of >80% at day 100 post-transplantation and a transplant related mortality rate of < or equal to 50%. A TRM of >50% will be considered unacceptable. The present research will also:
Ages Eligible for Study: | 18 Years to 55 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Disease types:
Exclusion Criteria:
United States, California | |
University of California, San Francisco | |
San Francisco, California, United States, 94143 |
Principal Investigator: | Thomas G. Martin, M.D. | University of California, San Francisco |
Study ID Numbers: | UC2207 |
Study First Received: | August 8, 2007 |
Last Updated: | March 3, 2008 |
ClinicalTrials.gov Identifier: | NCT00514722 History of Changes |
Health Authority: | United States: Institutional Review Board |
Hematopoietic malignancies Umbilical cord blood transplantation Lymphoma: diffuse large cell, mantle cell, peripheral T-cell, T-NK cell, or Hodgkin's |
Leukemia, Lymphoid Precancerous Conditions Hematologic Neoplasms Blood Protein Disorders Lymphoma, Mantle-Cell Mantle Cell Lymphoma Paraproteinemias Leukemia, Myeloid, Acute Hemostatic Disorders Lymphoma, T-Cell, Peripheral Lymphoma, B-Cell Leukemia Acute Myelocytic Leukemia Preleukemia Hemorrhagic Disorders |
Lymphoma, T-Cell Lymphoma, Large-cell Hodgkin Disease Lymphoma Acute Lymphoblastic Leukemia Lymphoma, Large B-Cell, Diffuse Precursor Cell Lymphoblastic Leukemia-Lymphoma Immunoproliferative Disorders Hodgkin Lymphoma, Adult Hematologic Diseases Blood Coagulation Disorders Myelodysplastic Syndromes Vascular Diseases Myeloproliferative Disorders Hodgkin's Disease |
Leukemia, Lymphoid Precancerous Conditions Hematologic Neoplasms Blood Protein Disorders Lymphoma, Mantle-Cell Paraproteinemias Hemostatic Disorders Leukemia, Myeloid, Acute Lymphoma, T-Cell, Peripheral Lymphoma, B-Cell Leukemia Preleukemia Neoplasms by Site Hemorrhagic Disorders Lymphoma, T-Cell |
Cardiovascular Diseases Lymphoma Hodgkin Disease Lymphoma, Large B-Cell, Diffuse Precursor Cell Lymphoblastic Leukemia-Lymphoma Neoplasms by Histologic Type Immunoproliferative Disorders Immune System Diseases Hematologic Diseases Myelodysplastic Syndromes Vascular Diseases Myeloproliferative Disorders Leukemia, Myeloid Multiple Myeloma Lymphatic Diseases |