Inclusion Criteria:

• BMI less or equal to 39 kg/m2
• Osteoarthritis (arthritis) of the knee or hip with pain score that qualifies
• Willing to comply with study visit schedule and study requirements, including, for women of child-bearing potential or male patients with female partners of child-bearing potential, the use of 2 forms of birth control, one of which is a barrier method.
• Patients must consent in writing to participate in the study.

Exclusion Criteria:

• Untreated, uncontrolled diseases,
• Unwilling or unable to discontinue the use of prohibited medications, including other pain medications, during the screening period and during the study,
• Significant cardiac disease within the past 6 months
• Significant neurological disease (e.g. peripheral neuropathy, multiple sclerosis, stroke) or signs of neuropathy at screening
• Known bleeding disorder or anticoagulation therapy
• Planned surgery during the study period
• History of alcoholism or drug abuse in the past 2 years
• Unable to use acetaminophen
• Use of a biologic (including live vaccines, with the exception of Flumist) within the past 3 months
• Allergic reaction to a biologic or an antibody in the past
• Disqualifying laboratory values, including Hepatitis B or C, HIV or drug test
• Cancer in the past 5 years. Basal cell or squamous cell carcinoma are okay.
• Medical condition that may interfere with study endpoints or safety of the subject as determined by the investigator.