Diurnal Intraocular Pressure and Peripapillary Retinal Blood Flow in Medically Controlled Open-Angle Glaucoma - Full Text View

Sponsored by:	Yonsei University
Information provided by:	Yonsei University
ClinicalTrials.gov Identifier:	NCT00481208

Purpose

Diurnal fluctuations of intraocular pressure (IOP) and peripapillary retinal blood flow may have distinctive patterns in medically well-controlled open-angle glaucoma patients. In the results, we found a unique pattern, 'Latent asymmetric IOP', defined as the IOP which differs between the eyes only when placed in the supine position. Unique effects of this latent asymmetric IOP on Visual field and diurnal IOP fluctuations were studied.

Condition
Open-Angle Glaucoma

Genetics Home Reference related topics: early-onset glaucoma

MedlinePlus related topics: Glaucoma

U.S. FDA Resources

Study Type:	Observational
Study Design:	Natural History, Cross-Sectional, Convenience Sample, Prospective Study
Official Title:	Diurnal Intraocular Pressure and Peripapillary Retinal Blood Flow in Medically Controlled Open-Angle Glaucoma

Further study details as provided by Yonsei University:

Enrollment:	70
Study Start Date:	March 2006
Study Completion Date:	November 2006

Detailed Description:

Diurnal fluctuations of intraocular pressure (IOP) and peripapillary retinal blood flow have been implicated to be one of the important factors to affect visual field progression. However, there was no study to investigate them in medically well-controlled open-angle glaucoma patients. So we want to find the unique patterns. Study 1. Subjects : Patients with medically well controlled open angle glaucoma Method : IOP and peripapillary retinal blood flow were measured for 24 hours. The relationship between the two were studied.

Study 2. Of the patients enrolled in study 1 , those on the same medical regimen for both eyes were analyzed for the presence of a latent asymmetric IOP and it's influence and association with visual field and diurnal IOP fluctuation.

Eligibility

Ages Eligible for Study:	20 Years to 70 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Open-angle glaucoma
Topical anti-glaucoma medications

Exclusion Criteria:

Ocular surgery history
Other ocular disease history
Oral glaucoma medications

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00481208

Locations

Korea, Republic of
Severance Hospital, Yonsei University College of Medicine
Seoul, Korea, Republic of, 120-752

Sponsors and Collaborators

Yonsei University

Investigators

Study Chair:

Chan Yun Kim, MD, PhD

Department of Ophthalmology, Yonsei University College of Medicine

More Information

No publications provided

Study ID Numbers:	4-2006-0146
Study First Received:	May 31, 2007
Last Updated:	May 31, 2007
ClinicalTrials.gov Identifier:	NCT00481208 History of Changes
Health Authority:	Republic of Korea: Institutional Review Board

Keywords provided by Yonsei University:

open-angle glaucoma
diurnal fluctuation
intraocular pressure
peripapillary retinal blood flow
latent asymmetric intraocular pressure

Study placed in the following topic categories:

Glaucoma
Eye Diseases
Glaucoma, Open-Angle
Hypertension
Ocular Hypertension

Additional relevant MeSH terms:

Glaucoma
Eye Diseases
Glaucoma, Open-Angle
Ocular Hypertension

ClinicalTrials.gov processed this record on May 07, 2009