Inclusion Criteria:

• age 18-65 years including males, females and minorities
• serum positive for either anti-HCV antibodies or HCV-RNA positive by PCR
• compensated liver disease with the following minimum hematologic and biochemical criteria: hemoglobin 13 g/dl for males; 12 g/dl for females, white blood cell count > 3,000/mm3, neutrophil count >1,5000/mm3, platelets > 100,000/mm3, prothrombin time  2 seconds prolonged compared to control, or equivalent INR ratio, albumin stable and within normal limits, serum creatinine within normal limits, thyroid-stimulating hormone (TSH) within normal limits, direct bilirubin 0.3 mg/dl or within 20% of upper limit of normal (ULN) for local laboratory, indirect bilirubin 0.8 mg/dl or within 20% of ULN for local laboratory, fasting blood sugar 115 mg/dl or within 20% of ULN for non-diabetic patients
• serum hepatitis B surface antigen (HbsAg) negative, antinuclear antibodies (ANA) 1:320
• normal pre-therapy ocular examination if a history of diabetes or hypertension
• hemoglobin A1C <8.5% if a history of diabetes
• negative pregnancy test for women of childbearing potential, and consent to adhere to adequate contraception or monogamous relationship with a male partner who has had a vasectomy during the treatment period and for 6 months after discontinuation of therapy
• not breast feeding
• documentation and confirmation of adequate contraception in sexually active males
• free from all psychotropic medications for a minimum of 14 days prior to baseline visit (8 weeks for fluoxetine)

Exclusion Criteria:

• actively meet criteria for major depression within the past six months
• active, effective treatment of depression with an antidepressant within the past three months
• meet criteria for schizophrenia or bipolar disorder (mania) past or present
• actively meet DSM IV criteria for substance abuse/dependence within the past six months
• psychotropic medications within 14 days prior to baseline visit (8 weeks for fluoxetine)
• evidence of untreated or poorly controlled endocrine, cardiovascular, hematological, renal, or neurological disease
• evidence of decompensated liver disease (such as a history or presence of ascites, bleeding varices, spontaneous encephalopathy)
• history of CNS trauma or active seizure disorder requiring medication
• any cause for liver disease other than chronic hepatitis C, such as co-infection with hepatitis B virus and/or human immunodeficiency virus, hemochromatosis, or Wilson’s disease
• prior treatment with other (other than IFN- or ribavirin) immunomodulatory drugs, including corticosteroids within 6 months of entry into protocol
• clinical gout
• known hypersensitivity to alpha interferon or ribavirin
• hemoglobinopathies (e.g. thalassemia)
• a positive pregnancy test
• clinically significant retinal abnormalities
• organ transplants
• a score of <24 on the Mini Mental Status Exam (MMSE)
• prior history of severe adverse events associated with paroxetine
• any other condition which in the opinion of the investigator would make the patient unsuitable for enrollment, or could interfere with participating in or completing the protocol