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Sponsors and Collaborators: |
Caritas St. Elizabeth's Medical Center of Boston Forest Laboratories |
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Information provided by: | Caritas St. Elizabeth's Medical Center of Boston |
ClinicalTrials.gov Identifier: | NCT00825825 |
Escitalopram (Lexapro) and citalopram (Celexa) are similar selective serotonin reuptake inhibitors that alter blood flow to the amygdala and other brain structures involved in regulating mood. Escitalopram consists of S-citalopram while citalopram contains both S-citalopram and R-citalopram (racemic citalopram). There is evidence that R-citalopram may block the effects of S-citalopram. The hypothesis being tested is that because of the antagonist effect of R-citalopram, S-citalopram will have a greater effect on the mood circuit than racemic citalopram when equal doses of S-citalopram are administered.
Condition | Intervention | Phase |
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Healthy |
Drug: Escitalopram Drug: Citalopram Drug: Placebo |
Phase IV |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double Blind (Subject, Investigator), Crossover Assignment |
Official Title: | A Comparison of the CNS Effects of Equivalent Doses of Escitalopram and Racemic Citalopram Using BOLD fMRI |
Estimated Enrollment: | 15 |
Study Start Date: | May 2007 |
Estimated Primary Completion Date: | December 2009 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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Escitalopram: Active Comparator
One week of escitalopram at 10 mg followed by one week at 20 mg in healthy volunteers.
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Drug: Escitalopram
One week of escitalopram taken orally at 10 mg followed by one week at 20 mg daily.
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Citalopram: Active Comparator
One week of citalopram at 20 mg followed by one week at 40 mg in healthy volunteers.
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Drug: Citalopram
One week of citalopram taken orally at 20 mg followed by one week at 40 mg daily.
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Placebo: Placebo Comparator
Two weeks of placebo in healthy volunteers.
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Drug: Placebo
Two weeks of placebo taken orally.
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Ages Eligible for Study: | 21 Years to 50 Years |
Genders Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: Tara Lauriat, PhD | 617-789-2404 | depression@caritaschristi.org |
United States, Massachusetts | |
Caritas St. Elizabeth's Medical Center | Recruiting |
Boston, Massachusetts, United States, 02135 | |
Contact: Tara Lauriat, PhD 617-789-2404 depression@caritaschristi.org | |
Principal Investigator: Michael E Henry, MD |
Principal Investigator: | Michael E Henry, MD | Caritas St. Elizabeth's Medical Center of Boston |
Responsible Party: | Caritas St. Elizabeth's Medical Center ( Michael E. Henry, MD, Chairman, Department of Psychiatry, Caritas St. Elizabeth's Medical Center ) |
Study ID Numbers: | 00397 |
Study First Received: | January 19, 2009 |
Last Updated: | January 26, 2009 |
ClinicalTrials.gov Identifier: | NCT00825825 History of Changes |
Health Authority: | United States: Institutional Review Board |
Citalopram Escitalopram Celexa Lexapro |
fMRI antidepressant healthy volunteers |
Neurotransmitter Agents Cholinergic Antagonists Psychotropic Drugs Healthy Cholinergic Agents Citalopram Serotonin Uptake Inhibitors |
Serotonin Muscarinic Antagonists Peripheral Nervous System Agents Dexetimide Antidepressive Agents, Second-Generation Antidepressive Agents |
Parasympatholytics Neurotransmitter Uptake Inhibitors Neurotransmitter Agents Cholinergic Antagonists Molecular Mechanisms of Pharmacological Action Anti-Dyskinesia Agents Physiological Effects of Drugs Psychotropic Drugs Antiparkinson Agents Cholinergic Agents Citalopram |
Serotonin Uptake Inhibitors Pharmacologic Actions Muscarinic Antagonists Serotonin Agents Autonomic Agents Therapeutic Uses Peripheral Nervous System Agents Dexetimide Antidepressive Agents, Second-Generation Central Nervous System Agents Antidepressive Agents |