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Sponsors and Collaborators: |
University of California, Irvine Doris Duke Charitable Foundation |
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Information provided by: | University of California, Irvine |
ClinicalTrials.gov Identifier: | NCT00824395 |
The purpose of this research study is to investigate the genetic causes of diabetes. Specifically, we are interested in the mitochondrial genome and how variants in the mitochondrial genome influence a person's risk to develop diabetes and metabolic syndrome.
Condition |
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Type 1 Diabetes Type 2 Diabetes Metabolic Syndrome |
Study Type: | Observational |
Study Design: | Case Control, Cross-Sectional |
Official Title: | Mitochondria and Metabolic Syndrome in a Southern California Chinese Cohort |
whole blood and serum
Estimated Enrollment: | 500 |
Study Start Date: | January 2006 |
Estimated Study Completion Date: | January 2009 |
Estimated Primary Completion Date: | January 2009 (Final data collection date for primary outcome measure) |
Groups/Cohorts |
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1
Individuals with diabetes
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2
Individuals without diabetes
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Since our laboratory's initial linkage of Type 2 diabetes to a mtDNA rearrangement in a three generation maternal pedigree 13 years ago, there has been increasing support for our hypothesis that mitochondrial dysfunction plays an important role in the etiology of Type 2 Diabetes Mellitus (DM) and the overlapping Metabolic Syndrome (MS). With this study we are planning an extensive investigation of defects in mitochondrial oxidative phosphorylation (OXPHOS) caused potentially by deleterious sequence variants in the mitochondrial DNA (mtDNA). As the primary objective we are trying to further substantiate 2 hypotheses: 1) that these diabetogenic mtDNA variants, which are proposed to range from recent, relatively severe, mutations will result in substantial OXPHOS defects with familial DM & MS and 2) that ancient, relatively mild polymorphisms result in partial OXPHOS defects and an increase in the risk to develop DM & MS.
Ages Eligible for Study: | 40 Years to 65 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
We are currently recruiting Chinese Americans living in Southern California, espcially in Orange and Los Angeles Counties. We are particularly in need of Chinese American men and women with diabetes as well as healthy male controls. We can arrange for offsite weekend trips to cities within LA or Orange Counties for eligible groups of 10 or more people.
Inclusion Criteria:
Exclusion Criteria:
Contact: Julia Platt, MS | 949-824-9232 | jplatt@uci.edu |
Contact: Shiqin Xu, PhD | 949-892-7645 | shiqinx@uci.edu |
United States, California | |
UC Irvine General Clinical Research Center | Recruiting |
Irvine, California, United States, 92697 | |
Contact: Julia Platt, MS 949-824-9232 jplatt@uci.edu |
Principal Investigator: | Douglas C Wallace, PhD | UC Irvine Center for Mitochondrial Medicine |
Responsible Party: | UC Irvine Center for Mitochondrial Medicine and Genetics ( Douglas C. Wallace, Ph.D / Principal Investigator ) |
Study ID Numbers: | 2005-4675 |
Study First Received: | January 15, 2009 |
Last Updated: | January 15, 2009 |
ClinicalTrials.gov Identifier: | NCT00824395 History of Changes |
Health Authority: | United States: Institutional Review Board |
diabetes type 1 type 2 metabolic syndrome mitochondria |
Autoimmune Diseases Metabolic Diseases Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus |
Endocrine System Diseases Diabetes Mellitus Type 1 Endocrinopathy Glucose Metabolism Disorders Metabolic Disorder |
Pathologic Processes Disease Autoimmune Diseases Metabolic Diseases Immune System Diseases Diabetes Mellitus, Type 1 |
Syndrome Diabetes Mellitus, Type 2 Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders |