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Sponsored by: |
University Health Network, Toronto |
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Information provided by: | University Health Network, Toronto |
ClinicalTrials.gov Identifier: | NCT00242671 |
The twilight phase between being asleep and awake during recovery from anesthesia is a precarious time fraught with risks to the post-operative patient.
Hyperventilation accelerates the elimination of inhaled anesthetics but reduces their CO2 blood concentrations which delays their resumption of spontaneous breathing. We previously showed that our method of hyperventilation without affecting the CO2 concentration--which we call IH--accelerates the rate of emergence from anesthesia with isoflurane. In this study we will study the effect of IH on the rate of emergence from Sevoflurane anesthesia.
Condition | Intervention | Phase |
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Anesthesia |
Procedure: Isocapnic Hyperponea |
Phase III |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Single Blind, Active Control, Parallel Assignment, Efficacy Study |
Official Title: | The Efficacy of Isocapnic Hyperpnoea to Accelerate Recovery After General Anesthesia With Sevoflurane. |
Ages Eligible for Study: | 18 Years to 80 Years |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | No |
Inclusion criteria:
Exclusion criteria:
Contact: Rita Katznelson, MD | 416-340-4800 ext 2840 | rita.katznelson@uhn.on.ca |
Canada, Ontario | |
Toronto General Hospital, University Health Network | Recruiting |
Toronto, Ontario, Canada, M5G 2C4 | |
Contact: Rita Katznelson, MD 416-340-4800 ext 2840 rita.katznelson@uhn.on.ca | |
Sub-Investigator: Leonid Minkovich, MD | |
Sub-Investigator: Joe Fisher, MD |
Principal Investigator: | Rita Katznelson, MD | Toronto General Hospital, University Health Network |
Study ID Numbers: | UHN REB 05-0299-AE |
Study First Received: | October 18, 2005 |
Last Updated: | October 10, 2006 |
ClinicalTrials.gov Identifier: | NCT00242671 History of Changes |
Health Authority: | Canada: Ethics Review Committee |
general anesthesia, hyperventilation, carbon dioxide, isocapnic hyperponea |
Anesthetics, Inhalation Anesthetics, General Hyperventilation Central Nervous System Depressants |
Anesthetics Platelet Aggregation Inhibitors Sevoflurane |
Anesthetics, Inhalation Anesthetics, General Therapeutic Uses Hematologic Agents Physiological Effects of Drugs Central Nervous System Depressants |
Anesthetics Platelet Aggregation Inhibitors Central Nervous System Agents Pharmacologic Actions Sevoflurane |