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Sponsored by: |
National Taiwan University Hospital |
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Information provided by: | National Taiwan University Hospital |
ClinicalTrials.gov Identifier: | NCT00674284 |
We study the relationship between patient outcomes and sequential changes of serum cortisol level.
Condition |
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Survival |
Study Type: | Observational |
Study Design: | Cohort, Retrospective |
Official Title: | Change of Serum Cortisol Levels in Patients Without Improvement in Intensive Care Unit |
Estimated Enrollment: | 80 |
Study Start Date: | February 2008 |
Estimated Study Completion Date: | May 2008 |
Estimated Primary Completion Date: | April 2008 (Final data collection date for primary outcome measure) |
Elevated corticosteroid level to meet physiologic needs during acute illness is a protective response for stress. This homeostasis is maintained by the hypothalamic-pituitary-adrenal (HPA) axis. However, inadequate response as corticosteroid insufficiency in critically ill patients is reported with increasing frequency, especially in severe sepsis and septic shock. Thus, corticosteroids could be beneficial for septic shock or severe acute illness.
Once considered as normal adrenal function, adrenal insufficiency may developed later with chronic critical illness as adrenal exhaustion syndrome. It is easily overlooked and is possible due to the chronic secretion of systemic cytokines or other HPA axis-suppressive substances. There is still no consensus how often adrenal function testing should be repeated, although a re-evaluation should be considered if clinical symptoms and signs suggest adrenal insufficiency or deteriorating clinical condition.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
All of the adult patients (age >18 years) admitted to the intensive care units of the National Taiwan University Hospital between January 2005 and December 2006 were surveyed.
Inclusion Criteria:
Exclusion Criteria:
Taiwan | |
Chao-Chi Ho | Recruiting |
Taipei, Taiwan, 100 | |
Contact: Chao-Chi Ho, PhD 886-2-2356-2905 ccho1203@ntu.edu.tw |
Study Director: | Chao-Chi Ho, MD | 1. Department of Internal Medicine, National Taiwan University Hospital |
Responsible Party: | National Taiwan University Hospital ( Chao-Chi Ho ) |
Study ID Numbers: | 200802022R |
Study First Received: | May 5, 2008 |
Last Updated: | May 5, 2008 |
ClinicalTrials.gov Identifier: | NCT00674284 History of Changes |
Health Authority: | Taiwan: Department of Health |
Hydrocortisone Cortisol succinate Critical Illness Hydrocortisone acetate Epinephrine |