Pulmonary Arterial Hypertension in Systemic Sclerosis

This study is currently recruiting participants.

Verified by IRCCS Policlinico S. Matteo, December 2007

First Received: February 6, 2008 Last Updated: February 15, 2008 History of Changes

Sponsored by:	IRCCS Policlinico S. Matteo
Information provided by:	IRCCS Policlinico S. Matteo
ClinicalTrials.gov Identifier:	NCT00617487

Purpose

The purpose of this study is to evaluate the role of stress echocardiography, compared to standard echocardiography in the early identification of pulmonary arterial hypertension in systemic sclerosis. To evaluate the role of BNP in this setting.To analyze data recorded with respect to the parameters commonly used for SSc evaluation (eg thorax HRCT, pulmonary function tests + DLCO, nailfold capillaroscopy, etc); these parameters are available starting for 1999.

Condition
Systemic Sclerosis Pulmonary Arterial Hypertension

Genetics Home Reference related topics: pulmonary arterial hypertension

MedlinePlus related topics: High Blood Pressure Scleroderma

U.S. FDA Resources

Study Type:	Observational
Study Design:	Cohort, Prospective
Official Title:	Stress Echocardiography in the Early Identification of Pulmonary Arterial Hypertension in Systemic Sclerosis

Further study details as provided by IRCCS Policlinico S. Matteo:

Biospecimen Retention: None Retained

Biospecimen Description:

Estimated Enrollment:	200
Study Start Date:	December 2007
Estimated Study Completion Date:	January 2009

Eligibility

Ages Eligible for Study:	18 Years to 90 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Probability Sample

Study Population

patients with systemic sclerosis

Criteria

Inclusion Criteria:

Patients with systemic sclerosis according to LeRoy criteria

Exclusion Criteria:

Pregnancy
Significant valvular disease
Low left ventricular function upon echocardiography (ejection fraction<55%)
History of atrial fibrillation, myocardial infarction, pulmonary thromboembolisms, neoplasia or severe hepatic disease.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00617487

Contacts

Contact: Lorenzo Cavagna, MD

00390382501878

lorenzo.cavagna@unipv.it

Locations

Italy, PV
IRCCS Foundation Policlinico S. Matteo	Recruiting
Pavia, PV, Italy, 27100
Contact: Lorenzo Cavagna, MD 00390382 ext 501878 lorenzo.cavagna@unipv.it
IRCCS Policlinico S. Matteo	Recruiting
Pavia, PV, Italy, 27100
Principal Investigator: Stefano Ghio, MD

Sponsors and Collaborators

IRCCS Policlinico S. Matteo

Investigators

Study Director:	Stefano Ghio, MD	IRCCS Foundation Policlinico S. Matteo, Cardiology
Principal Investigator:	Lorenzo Cavagna, MD	University and IRCCS Foundation Policlinico S. Matteo, Rheumatology

More Information

No publications provided

Responsible Party:	Cardiology Unit IRCCS Foundation Policlinico S. Matteo, Pavia ( Dr Ghio Stefano )
Study ID Numbers:	EchostressSSc
Study First Received:	February 6, 2008
Last Updated:	February 15, 2008
ClinicalTrials.gov Identifier:	NCT00617487 History of Changes
Health Authority:	Italy: National Monitoring Centre for Clinical Trials - Ministry of Health

Study placed in the following topic categories:

Skin Diseases
Vascular Diseases
Stress
Sclerosis
Respiratory Tract Diseases
Hypertension, Pulmonary
Lung Diseases

Connective Tissue Diseases
Idiopathic Pulmonary Hypertension
Scleroderma, Diffuse
Scleroderma
Scleroderma, Systemic
Hypertension

Additional relevant MeSH terms:

Pathologic Processes
Skin Diseases
Respiratory Tract Diseases
Hypertension, Pulmonary
Lung Diseases
Connective Tissue Diseases

Vascular Diseases
Scleroderma, Diffuse
Cardiovascular Diseases
Sclerosis
Scleroderma, Systemic
Hypertension

ClinicalTrials.gov processed this record on May 07, 2009