Inclusion Criteria:

1. Male and female;
2. between the ages of 21 and 50 years;
3. medically and neurologically healthy on the basis of history, physical examination, EKG, screening laboratories (CBC w/ differential, TSH, free-T4, AST, ALT, GGT, BUN, creatinine, calcium, phosphorous, magnesium, total protein, albumin, electrolytes, VDRL, urinalysis, serum beta-HCG for women of childbearing potential);
4. currently smoking cigarettes (no more than 1 pack per day; subjects who smoke pipes and/or cigars only will be excluded) and not interested in stopping smoking or not currently smoking but have tried cigarettes in the past;
5. have had at least 4 drinks on at least 2 occasions in the past year and are not interested in stopping drinking;
6. absence of current and past substance abuse, with the exception of alcohol abuse on the basis of history and urine toxicology and breath alcohol levels at screening and on each test day.

Exclusion Criteria:

1. Present or past DSM-IV psychiatric and substance abuse/dependence, with the exception of alcohol, diagnosis by history and psychiatric evaluation including a Structured Clinical Interview for DSM-IV Non-Patient (SCID-NP)(45);
2. Subjects who meet criteria for alcohol abuse and express an interest in stopping alcohol use and/or express an interest in treatment or are currently enrolled in treatment for alcoholism, or have sought treatment in the last 6 months;
3. history of counseling or psychotherapy, except family therapy centered around another family member or marital therapy;
4. for women of childbearing potential: positive pregnancy test or refusal to use contraception during the study;
5. alcohol and/or nicotine naïve;
6. history of psychosis in first degree relative.