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Sponsors and Collaborators: |
Rockefeller University Emory University |
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Information provided by: | Rockefeller University |
ClinicalTrials.gov Identifier: | NCT00616356 |
The investigators at Rockefeller University are doing this research to study how the immune system responds to viruses and other infectious agents by using the yellow fever 17D vaccine as a model. The YFV-17D vaccine is one of the safest and most effective vaccines known and has been used to vaccinate humans against yellow fever virus (YFV) infection since the 1930s. By studying how the human immune system responds to the YFV vaccine we hope to learn more about the normal functioning of the immune system so that it might be possible to design new, more effective types of vaccines to prevent important infectious diseases.
The reason for doing this research is:
Currently there is very little information about which factors determine the effectiveness of the initial (primary) immune response to a foreign substance (antigen), such as a virus, that person may be exposed to. There is also very little known about what determines how effectively and for how long a person's immune system can react to the same antigen to prevent another infection. Studies in animals have given us important information about how the immune systems of other animals behave upon initial or repeated exposure to antigens,but these topics have not been studied in detail in humans.
The following hypotheses will be tested:
Condition |
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Yellow Fever |
Study Type: | Observational |
Study Design: | Case-Only, Cross-Sectional |
Official Title: | Characterization of T Cell Responses Following Yellow Fever Virus Vaccination in Healthy Adults |
Ages Eligible for Study: | 18 Years to 45 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Rockefeller University Personnel
Inclusion Criteria:
Exclusion Criteria:
United States, New York | |
Rockefeller University | |
New York, New York, United States, 10021 |
Principal Investigator: | Charles M Rice, PhD | Rockefeller University |
Responsible Party: | The Rockefeller University ( Charles M. Rice, PhD ) |
Study ID Numbers: | RUH IRB # CRI-0618 |
Study First Received: | January 23, 2008 |
Last Updated: | July 2, 2008 |
ClinicalTrials.gov Identifier: | NCT00616356 History of Changes |
Health Authority: | United States: Food and Drug Administration |
Yellow Fever |
Virus Diseases Fever Signs and Symptoms |
Yellow Fever Healthy Arbovirus Infections |
Virus Diseases Fever Signs and Symptoms RNA Virus Infections Yellow Fever |
Flaviviridae Infections Flavivirus Infections Arbovirus Infections Body Temperature Changes |