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| Sponsored by: |
University of California, Irvine |
|---|---|
| Information provided by: | University of California, Irvine |
| ClinicalTrials.gov Identifier: | NCT00703443 |
Purpose
The purpose of this study is to determine the genetic basis of cardiomyopathies and heart failure.
| Condition |
|---|
|
Dilated Cardiomyopathy Hypertrophic Cardiomyopathy Mitochondrial Cardiomyopathy Noncompaction Cardiomyopathy Restrictive Cardiomyopathy |
| Study Type: | Observational |
| Study Design: | Family-Based, Retrospective |
| Official Title: | The Genetics of Cardiomyopathy and Heart Failure |
Whole blood, Saliva, Buccal cells
| Estimated Enrollment: | 200 |
| Study Start Date: | April 2007 |
| Estimated Study Completion Date: | January 2015 |
| Estimated Primary Completion Date: | January 2015 (Final data collection date for primary outcome measure) |
The purpose of this research study is to explore the causes and inheritances of cardiomyopathies. Cardiomyopathies are serious medical conditions that result in a wide range of cardiac problems, from no symptoms at all to heart failure. The underlying genetics of cardiomyopathies are poorly understood.
This study will collect personal, family, and medical history information to create a database of participants with cardiomyopathies. This information will be used to identify inheritance patterns within families with cardiomyopathies. In addition, samples from participants will be studied in the lab to see if any changes in their genetic information can be identified that would cause a cardiomyopathy. Overall, the research study is aimed at determining the cause of these cardiac conditions so that tests and treatments might be developed in the future.
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
We are recruiting both local participants (who have been evaluated at UCI) and remote participants (who have been referred from outside UCI) with familial and simplex cases of hypertrophic, dilated, noncompaction, restrictive, and mitochondrial cardiomyopathies. As a control group, we are also recruiting patients with nuclear mutations known to increase the risk of cardiomyopathy, but who have not themselves developed cardiomyopathy.
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| United States, California | |
| University of California, Irvine | |
| Irvine, California, United States, 92697 | |
| Principal Investigator: | Michael V Zaragoza, M.D., Ph.D. | University of California, Irvine |
More Information
| Responsible Party: | University of California, Irvine ( Michael V. Zaragoza, M.D., Ph.D., Assistant Clinical Professor ) |
| Study ID Numbers: | HS# 2007-5577, NIH/NHLBI 5K08HL081222-02 |
| Study First Received: | June 19, 2008 |
| Last Updated: | April 8, 2009 |
| ClinicalTrials.gov Identifier: | NCT00703443 History of Changes |
| Health Authority: | United States: Institutional Review Board |
|
Genetics Dilated Cardiomyopathy Hypertrophic Cardiomyopathy Mitochondrial Cardiomyopathy |
Noncompaction Cardiomyopathy Restrictive Cardiomyopathy Heart Failure |
|
Pathological Conditions, Anatomical Heart Failure Heart Diseases Dilated Cardiomyopathy Cardiomyopathy, Dilated Constriction, Pathologic Cardiomyopathies |
Heart Valve Diseases Cardiomyopathy, Restrictive Hypertrophy Cardiomyopathy, Hypertrophic Aortic Valve Stenosis Cardiomegaly |
|
Pathological Conditions, Anatomical Heart Failure Heart Diseases Cardiomyopathy, Dilated Cardiomyopathies Heart Valve Diseases Cardiomyopathy, Restrictive |
Hypertrophy Aortic Stenosis, Subvalvular Cardiomyopathy, Hypertrophic Cardiovascular Diseases Aortic Valve Stenosis Cardiomegaly |
