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Sponsored by: |
National Center for Research Resources (NCRR) |
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Information provided by: | National Center for Research Resources (NCRR) |
ClinicalTrials.gov Identifier: | NCT00005767 |
This protocol seeks to define aspects of intestinal and hepatic uptake and metabolism of several amino acids. The major hypothesis to be tested is that the splanchic bed (intestine and liver) conserves essential amino acids and metabolites while synthesizing and metabolizing nonessential amino acids.
The aims of the study include defining the relative roles of enteral and hepatic extraction/metabolism in the disposition of glutamate, alanine, methionine and other amino acids. Emphasis will also be placed on studies of the transamination of alpha-ketoisocaproic acid (KIC) to leucine since this reaction is of potential importance in the design of nutritional regimens for patients with renal disease.
Condition |
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Kidney Diseases |
Study Type: | Observational |
Study Design: | Natural History, Cross-Sectional |
Ages Eligible for Study: | 18 Years to 55 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: Dwight Matthews, Ph.D. | 1-802-646-8114 |
United States, Vermont | |
University of Vermont | Recruiting |
Burlington, Vermont, United States, 05401 | |
Contact: Dwight Matthews, Ph.D. 802-646-8114 |
Study ID Numbers: | NCRR-M01RR00109-0740, M01RR00109 |
Study First Received: | June 1, 2000 |
Last Updated: | June 23, 2005 |
ClinicalTrials.gov Identifier: | NCT00005767 History of Changes |
Health Authority: | United States: Federal Government |
Amino Acid Metabolism |
Urologic Diseases Kidney Diseases |
Urologic Diseases Kidney Diseases |